Showing papers in "International Journal of Pharmaceutics in 2007"
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TL;DR: Cyclodextrins are still regarded as novel excipients of unexplored potential and, thus, 100 years after their discovery, new cyclodextrin-based technologies are constantly being developed.
1,394 citations
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TL;DR: It is proved that curcumin-phospholipid complex has better hepatoprotective activity, owe to its superior antioxidant property, than freeCurcumin at the same dose level.
745 citations
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TL;DR: The present review provides an in-depth discussion of therapeutic aspects of IN delivery including consideration of the intended indication, regimen, and patient population, as well as physicochemical properties of the drug itself.
515 citations
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TL;DR: An overview of theDevelopment of lipid vesicles for skin delivery of drugs, with special emphasis on recent advances in this field, including the development of deformable liposomes and ethosomes is provided.
469 citations
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TL;DR: Focus is placed on especially interesting improvements such as nanoparticles for the delivery of drugs across the blood-brain barrier (BBB) and PEGylated nanoparticles with a prolonged blood circulation time.
426 citations
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TL;DR: Predictive ability and quick methods for assessment of such problems could be very useful to the formulators in selecting lead formulations, and this review will attempt to summarize the research work that could be useful in developing these tools.
392 citations
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TL;DR: The results revealed that after storage in the absence of sunlight for 6 months, the percentages of the remaining curcumin, bisdemethoxyCurcumin and demethoxycurcumin were 91, 96 and 88, respectively.
390 citations
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TL;DR: It was determined that the particle size of haloperidol-loaded PLGA/PLA nanoparticles is effectively controlled by the amount of shear stress transferred from the energy source to the organic phase, which is strongly correlated to the following parameters: type of applied energy, aqueous phase volume, and polymer concentration in the organic solvent.
371 citations
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TL;DR: Biodistribution studies in breast cancer xenografted nude mouse model showed that the PEGylated liposome showed greater tumor growth inhibition effect in in vivo studies and could serve as a better alternative for the passive targeting of human breast tumors.
363 citations
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TL;DR: Results indicate that the studied IT-SLN formulation with skin targeting may be a promising carrier for topical delivery of isotretinoin.
362 citations
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TL;DR: The optimized CFP SNEDDS needed surfactant content less than 40% and yielded nanoemulsion of mean globule size 170 nm, which was not affected by the pH of dilution medium, which helped to overcome problems associated with the delivery of cefpodoxime proxetil.
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TL;DR: The therapeutic value of psyllium for the treatment of constipation, diarrhea, irritable bowel syndrome, inflammatory bowel disease-ulcerative colitis, colon cancer, diabetes and hypercholesterolemia is discussed and exploitation of psyLLium for developing drug delivery systems is discussed.
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TL;DR: The skin irritation studies carried out on rabbits showed that SLN based TRE gel is significantly less irritating to skin as compared to marketed TRE cream and clearly indicated its potential in improving the skin tolerability of TRE.
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TL;DR: Thermal analysis of the API-polymer-surfactant blends suggested that the surfactants caused solvation/plasticization, manifesting in reduction of the melting of API and T(m) of polymers and the combined T(g) of the solid dispersion formed from quench cooling.
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TL;DR: The purpose of this article is to review USP and non-pharmacopeial dissolution testing methods for conventional and novel pharmaceutical dosage forms and give an insight to possible alternatives in drug dissolution study design and appropriate choices for dissolution media.
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TL;DR: Presence of guar gum and glutaraldehyde crosslinking increases entrapment efficiency and prevents the rapid dissolution of alginate in higher pH of the intestine, ensuring a controlled release of the entrapped drug.
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TL;DR: Curcumin is more active than the derivatives investigated and that the free phenolic hydroxyl group may be essential for the scavenging properties, and the two halves of the symmetric curcumin molecule act as two separate units and scavenge one radical each.
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TL;DR: The high pressure homogenization method used to prepare nanosuspensions of three practically insoluble glucocorticoid drugs shows that compared to solution and micro-crystalline suspensions it is a common feature of the three drugs that the nanos Suspensions always enhance the rate and extent of ophthalmic drug absorption as well as the intensity of drug action.
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TL;DR: In this paper, the authors investigated the influence of process parameters on microsphere morphology and burst release of FD40 from biodegradable microspheres in the initial release phase characterized by pore diffusion.
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TL;DR: A standard protocol for the preparation of doxorubicin-loaded HSA nanoparticles for further antitumoural studies was established and the anti-cancer effects of the drug-loaded nanoparticles were increased in comparison to doxorbicin solution.
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TL;DR: Results indicate that niosomes could be developed as sustained release oral dosage forms for delivery of peptides and proteins such as insulin.
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TL;DR: Differential scanning calorimetry and X-ray diffraction demonstrated that the drug was molecularly dispersed within the nanoparticles whereas the non-encapsulated DXM crystallized, demonstrating the feasibility of encapsulating dexamethasone and its subsequent delivery.
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TL;DR: Results of stability evaluation showed a relatively long-term stability after storage at 4 degrees C for 6 months and SLNs with small particle size, excellent physical stability, high entrapment efficiency, good loading capacity for protein drug can be produced by this novel reverse micelle-double emulsion method.
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TL;DR: The sustained release profiles of single and dual crosslinked gel beads loaded bovine serum albumin, a model protein drug, were investigated in simulated gastric fluid, simulated intestinal fluid and simulated colonic fluid to suggest that the dual crosslinkage beads have potential small intestine or colon site-specific drug delivery property.
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TL;DR: The structure, size, morphology, magnetic property and relaxivity of the SPION-alginate were characterized systematically by means of XRD, TEM, ESEM, AFM, DLS, SQUID magnetometer and MRI, respectively, and the interaction between alginate and iron oxide (Fe(3)O(4)) was characterized by FT-IR and AFM.
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TL;DR: The results showed that the dissolution rate of liquisolid tablets was not significantly affected by storing the tablets at 25 degrees C/75% relative humidity for a period of 6 months, and the results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between carbamazepine and exipients during the process.
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TL;DR: In general, nanoparticle production was satisfactory when the initial organic solution of polymer was in the dilute rather than the semi-dilute regime, and acetone, which acted as a theta solvent for PLA, always led to smaller particles and better yields than THF.
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TL;DR: The results indicate that the amounts of opsonins associated on nanoparticles would change over time and this process would be substantially reflected in the alteration of their hepatic disposition characteristics.
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TL;DR: It is suggested that the combined mechanisms of folate-mediated active internalization and Pluronic-mediated overcoming MDR be beneficial in treatment of MDR solid tumors by targeting delivery of micellar PTX into the tumor cells where folate receptor is frequently overexpressed, reducing accumulation of micella PTX in other tissues or organs and further reducing side effects and toxicities of the drug.
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TL;DR: It was found that AP-loaded NLC prepared and stored in non-degassing conditions, a higher percentage of AP loading in NLC, lower storage temperature, addition of antioxidants as well as selection of suitable surfactants and solid lipids improved the chemical stability of AP.