Compounds of formula (1) are described and the salts, solvates, hydrates and N-oxides thereof, in which R?1, R2, R3, R4, R5, R6 and R7? have the meanings given in Claim 1. The compounds are selective inhibitors of protein kinases, especially src-family protein kinases and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to have a role.

Substituted 2-anilinopyrimidines useful as protein kinase inhibitors

C-vinylpyrroles as pyrrole building blocks.

Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R1 is a hydrogen atom or a straight or branched chain alkyl group; R2 is a -X1-R3 group where X1 is a direct bond or a linker atom or group, and R3 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR Kinase and/or FGFr Kinase inhibitors and are of use in the prophylaxis and treatment of disease states associated with angiogenesis.

5-Cyano-2-aminopyrimidine derivatives

Compounds are described in formula (1), wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; R2 is an optionally substituted cycloalkyl or cycloalkenyl group; R3 is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, nitrogen or sulphur atoms or a group -N(R4)- where R4 is a hydrogen atom or an alkyl group; X is -O-, -S-, or -N(R5)-, where R5 is a hydrogen atom or an alkyl group; with the proviso that when X is -O- the R3 is not a 3-cyanamino-6-pyridazinyl or a 3-chloro-6-pyridazinyl group; and the salts, solvates, hydrates and N- oxides thereof. The compounds are selective phosphodiesterase IV inhibitors and are useful for the prophylaxis or treatment of inflammatory diseases.

Tri-substituted phenyl derivatives and processes for their preparation

Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies Silvia Schenone,*,† Marco Radi,‡ Francesca Musumeci,† Chiara Brullo,† and Maurizio Botta †Dipartimento di Farmacia, Universita ̀ degli Studi di Genova Viale Benedetto XV, 3, 16132 Genova, Italy ‡Dipartimento di Farmacia, Universita ̀ degli Studi di Parma Viale delle Scienze, 27/A, 43124 Parma, Italy Dipartimento di Biotecnologie, Chimica e Farmacia, Universita ̀ degli Studi di Siena Via Aldo Moro, 2, 53100 Siena, Italy Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, United States

Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies.

Polarized ethylenes. IV. Synthesis of polarized ethylenes using thioamides and methyl dithiocarboxylates and their application to syntheses of pyrazoles, pyrimidines, pyrazolo[3,4‐d]pyrimidines, and 5‐aza[2.2.3]cyclazines

Yoshimitsu Uchimura

Papers

Polarized ethylenes. IV. Synthesis of polarized ethylenes using thioamides and methyl dithiocarboxylates and their application to syntheses of pyrazoles, pyrimidines, pyrazolo[3,4‐d]pyrimidines, and 5‐aza[2.2.3]cyclazines