2,5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products.

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

BIOCHEMICAL MECHANISM OF CO-METABOLISM ............ 147 CO-METABOLISM OF ENVIRONMENTAL POLLUTANTS BY PURE CULTURES OF MICROORGANISMS ...... ....................... 149 CO-METABOLISM OF ENVIRONMENTAL POLLUTANI'S BY NATURALLY OCCURRING MICROBIALPOPULATIONS. .. .............. 150 A NEW LOOK AT MOLECULAR RECALCITRANCE ...... 151 CO-METABOLISM AS A BIOCHEMICAL TECHNIQUE ... 153 LITERATURE CITED............................................. 154

Microbial co-metabolism and the degradation of organic compounds in nature.

Research on natural products containing hexahydropyrrolo[2,3-b]indole (HPI) has dramatically increased during the past few years. Newly discovered natural products with complex structures and important biological activities have recently been isolated and synthesized. This review summarizes the structures, biological activities, and synthetic routes for natural compounds containing HPI, emphasizing the different strategies for assembling this motif. It covers a broad range of molecules, from small alkaloids to complex peptides.

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Structure, Bioactivity and Synthesis of Natural Products with Hexahydropyrrolo[2,3‐b]indole

Biosynthesis of polyketides by trans-AT polyketide synthases

This invention relates to a novel imidazopyridine compound represented by formula (I), wherein X is vinylene, or a group of the formula (a), Y is heterocyclic group which may have one or more suitable substituent(s), or aryl which may have one or more suitable substituent(s), Q is CH or N, and 1 is an integer of 0 or 1, which are the inhibitors of bone resorption and bone metabolism, to processes for preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of diseases caused by abnormal bone metabolism in human being or an animal.

Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors

Structure of amauromine, a new hypotensive vasodilator produced by amauroascus sp.

A complex of the new antitumor antibiotics (WF-1360, WF-1360A, B, C, D, E and F) was produced by Rhizopus sp. No. F-1360. Structural studies of these compounds suggested that they were novel 16-membered-ring lactones having an oxazole ring in their structures. WF-1360 was found to be identical with rhizoxin (1) and WF-1360B, C, E and F were de-termined to be homologues of 1 with structures 2, 3, 4 and 5, respectively. These compounds were cytotoxic when tested on P388 leukemia cells in vitro. WF-1360 was highly active against leukemia L1210 and melanoma B16. They also exhibited potent antifungal activities, but weak antimicrobial activities against some Gram-positive or negative bacteria.

A new antitumor complex, WF-1360, WF-1360A, B, C, D, E and F.

The present invention relates to a new heterocyclic compound of formula (I), wherein R1 is acyl, lower alkenyl or lower alkyl optionally substituted with aryl, a heterocyclic group, etc., R2 is hydrogen, lower alkyl, hydroxy(lower)alkyl, halo(lower)alkyl, etc., R3 is hydrogen or halogen, R4 is a heterocyclic group or aryl, each of which may be substituted with suitable substituent(s), and A is (a) or (b), (wherein R?9 and R10? are each hydrogen, lower alkyl or substituted lower alkyl), and pharmaceutically acceptable salts thereof which are the inhibitors of bone resorption and bone metabolism, to processes for preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of diseases caused by abnormal bone metabolism in human being or an animal.

Yoshio Kawai

Papers

Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors

Structure of amauromine, a new hypotensive vasodilator produced by amauroascus sp.

A new antitumor complex, WF-1360, WF-1360A, B, C, D, E and F.

Benzimidazole derivatives and their use in the prevention and/or the treatment of bone diseases

Structure of amauromine, a new alkaloid with vasodilating activity produced by sp.