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Yoshitaka Nagahama
Researcher at Ehime University
Publications - 120
Citations - 10851
Yoshitaka Nagahama is an academic researcher from Ehime University. The author has contributed to research in topics: Sexual differentiation & Oryzias. The author has an hindex of 47, co-authored 120 publications receiving 9831 citations. Previous affiliations of Yoshitaka Nagahama include Graduate University for Advanced Studies & National Institute for Basic Biology, Japan.
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Journal ArticleDOI
Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences
TL;DR: The lability of sex-determination systems in fish makes some species sensitive to environmental pollutants capable of mimicking or disrupting sex hormone actions, and such observations provide important insight into potential impacts from endocrine disruptors, and can provide useful monitoring tools for impacts on aquatic environments.
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DMY is a Y-specific DM-domain gene required for male development in the medaka fish
Masaru Matsuda,Yoshitaka Nagahama,Ai Shinomiya,Tadashi Sato,Chika Matsuda,Tohru Kobayashi,Craig E. Morrey,Naoki Shibata,Shuichi Asakawa,Nobuyoshi Shimizu,Hiroshi Hori,Satoshi Hamaguchi,Mitsuru Sakaizumi +12 more
TL;DR: Rec recombinant breakpoint analysis is used to restrict the sex-determining region in medaka fish to a 530-kilobase stretch of the Y chromosome, and it is suggested that thesex-specific DMY is required for testicular development and is a prime candidate for the medaka sex-Determining gene.
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Gonadal sex differentiation in teleost fish
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Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus
Shigeho Ijiri,Hiroyo Kaneko,Tohru Kobayashi,Deshou Wang,Deshou Wang,Fumie Sakai,Bindhu Paul-Prasanth,Masaru Nakamura,Yoshitaka Nagahama +8 more
TL;DR: It is concluded that the sex-specific expression of foxl2 and cyp19a1a in XX gonads and dmrt1 in XY gonads during early gonadal differentiation is critical for undifferentiated gonads to differentiate into either the ovary or testis in the Nile tilapia.
Journal ArticleDOI
Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes
Tohru Kobayashi,Masaru Matsuda,Masaru Matsuda,Hiroko Kajiura-Kobayashi,Aya Suzuki,Noriko Saito,Masatoshi Nakamoto,Naoki Shibata,Yoshitaka Nagahama +8 more
TL;DR: It is suggested strongly that DMY regulates PGC proliferation and differentiation sex‐specifically during early gonadal differentiation of XY individuals and that DMRT1 regulates spermatogonial differentiation.