Y
Youichi Sugenoya
Researcher at Showa University
Publications - 13
Citations - 282
Youichi Sugenoya is an academic researcher from Showa University. The author has contributed to research in topics: Mesangial cell & Glomerulonephritis. The author has an hindex of 8, co-authored 13 publications receiving 275 citations.
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Journal ArticleDOI
Simvastatin suppresses glomerular cell proliferation and macrophage infiltration in rats with mesangial proliferative nephritis.
Ashio Yoshimura,Kiyoko Inui,Takashi Nemoto,Susumu Uda,Youichi Sugenoya,Susumu Watanabe,Naoko Yokota,Takayasu Taira,Shigeki Iwasaki,Terukuni Ideura +9 more
TL;DR: This study examines the effect of simvastatin on glomerular pathology in a rat mesangial proliferative glomerulonephritis induced by anti-thymocyte antibody and finds the first report to find that Mesangial cell proliferation and matrix expansion have been blocked by simvastsatin in vivo.
Journal Article
Identification of the Transcriptional Regulatory Sequences of Human Calponin Promoter and Their Use in Targeting a Conditionally Replicating Herpes Vector to Malignant Human Soft Tissue and Bone Tumors
Hisako Yamamura,Miho Hashio,Mika Noguchi,Youichi Sugenoya,Masakazu Osakada,Noriko Hirano,Yumiko Sasaki,Takahiro Yoden,Nobuhisa Awata,Nobuhito Araki,Masaharu Tatsuta,Shin-Ichi Miyatake,Katsuhito Takahashi +12 more
TL;DR: Results indicate that replication-competent virus vectors controlled by the calponin transcriptional regulatory sequence may be a new therapeutic strategy for treatment of malignant human soft tissue and bone tumors.
Journal ArticleDOI
Effect of simvastatin on proliferative nephritis and cell-cycle protein expression.
Ashio Yoshimura,Takashi Nemoto,Youichi Sugenoya,Kiyoko Inui,Susumu Watanabe,Yoshihiko Inoue,Sakineh Sharif,Naoko Yokota,Susumu Uda,Hiroyuki Morita,Terukuni Ideura +10 more
TL;DR: Simvastatin suppressed mesangial cell proliferation and subsequent matrix expansion, and macrophage infiltration into glomeruli in anti-Thy 1.1 GN rats.
Journal ArticleDOI
Smooth-muscle calponin in mesangial cells: Regulation of expression and a role in suppressing glomerulonephritis
Youichi Sugenoya,Ashio Yoshimura,Hisako Yamamura,Kiyoko Inui,Hiroyuki Morita,Hideaki Yamabe,Noboru Ueki,Terukuni Ideura,Katsuhito Takahashi +8 more
TL;DR: Results suggest that basic calponin expression may serve as one of the intrinsic regulators of glomerular nephritis and improve the understanding of the molecular basis and pathogenesis of the glomersular response to injury.
Journal ArticleDOI
Expression of bcl-2 and bax in glomerular disease.
Ashio Yoshimura,Susumu Uda,Kiyoko Inui,Takashi Nemoto,Youichi Sugenoya,S Sharif,Naoko Yokota,S. Watanabe,Terukuni Ideura +8 more
TL;DR: The balance of bcl-2/bax expression may be critical in the course of human glomerular diseases and TGF-beta1 participates in this process by increasing bax expression.