Showing papers by "Youn-Chul Kim published in 2002"
TL;DR: Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether, which showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.62 micro, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
Abstract: Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC(50) = 23.4 +/- 1.5 microM). Compounds 2 and 4 showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.42 and 32.3 +/- 2.62 micro, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
119 citations
TL;DR: The results suggest that luteolin may be used as potential chemopreventive and chemotherapeutic agents.
Abstract: Luteolin, a flavonoid isolated from the fruit of Vitex rotundifolia, has been examined with regard to the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia HL-60 cells. The concentration required for 50% inhibition of the growth after 96 h was 15 +/- 1.1 microM. The mode of cell death induced by luteolin was found to be apoptosis, as judged by the morphologic alteration of the cells and by the detection of DNA fragmentation using agarose gel electrophoresis. The degree of apoptosis was quantified by a sandwich enzyme immunoassay and flow cytometric analysis. These results suggest that luteolin may be used as potential chemopreventive and chemotherapeutic agents.
92 citations
TL;DR: Comparison of hepatoprotective activities for six furocoumarins 1 - 6 suggested that oxy-substitution at the C-9 position increased the hepatoprotsective activity.
Abstract: Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4), (+)-byakangelicin (5), and (+)-aviprin (6). Among these, compounds 1 and 5 exhibited strong hepatoprotective activities, displaying EC(50) values of 36.6 +/- 0.98 and 47.9 +/- 4.6 microM, respectively. Compounds 3 and 4 showed moderate activities with EC(50) values of 112.7 +/- 5.35 and 286.7 +/- 6.36 microM, respectively. Silybin as a positive control showed the EC(50) value with 69.0 +/- 3.4 microM. Comparison of hepatoprotective activities for six furocoumarins 1 - 6 suggested that oxy-substitution at the C-9 position increased the hepatoprotective activity.
48 citations
TL;DR: Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri furnished two hepatoprotective sesquiterpenes, torilin and torilolone, together with a new derivative, 1-hydroxytorilin (3), which showed hepatop rotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
Abstract: Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and torilolone (2), together with a new derivative, 1-hydroxytorilin (3). Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 +/- 1.86 (P < 0.01) and 3.6 +/- 0.1 (P < 0.01) microM, respectively. Silybin as a positive control showed an EC50 value of 69.0 +/- 3.4 microM.
37 citations
TL;DR: This study identifies and delineates signaling factors involved in the antiapoptotic properties of Sm-X and suggests a potential application of S. miltiorrhiza in the clinical management of hepatic disease induced by toxic bile salts following biliary obstruction.
31 citations
TL;DR: A series of 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid 6, were synthesized and evaluated for their antitumor activity.
11 citations
Patent•
24 Apr 2002
TL;DR: In this paper, a novel sulfonamide derivatives and intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly, to novel SDS derivatives that are used as angiogenesis controlling material and that can inhibit overexpression of matrix metalloproteinase that decomposes protein constituents in extracellular and basement membranes of connective tissues.
Abstract: The present invention relates to a novel sulfonamide derivatives and novel intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly, to novel sulfonamide derivatives and intermediates thereof that are used as angiogenesis controlling material and that can inhibit overexpression of matrix metalloproteinase that decomposes protein constituents in extracellular and basement membranes of connective tissues, and preparation methods thereof, and a pharmaceutical composition comprising the same.
7 citations
Patent•
31 May 2002
TL;DR: In this article, a Korean Acanthopanax Senticosus extract, a protein extract and crude protein polysaccharide derived therefrom, and an immuno-regulating composition comprising the same as an ative ingredient and the use thereof, were presented.
Abstract: The present invention relates to a Korean Acanthopanax Senticosus extract, a protein extract and crude protein polysaccharide derived therefrom, and an immuno-regulating composition comprising the same as an ative ingredient and the use thereof, and more particularly to a Korean Acanthopanax Senticosus extract and a protein extract and crude protein polysaccharide derived therefrom, which are have effective in increasing immunity and have superior anti-allergy effects and thus can be used as an active ingredient for functional foods, cosmetics, and pharmaceutical compositions, and as an immuno-regulating compositoin comprising the same as an active ingredient and the use thereof.
2 citations
TL;DR: A series of 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluoric acid 6, were synthesized and evaluated for their antitumor activity as discussed by the authors.
Abstract: A series of 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid 6, were synthesized and evaluated for their antitumor activity.
Patent•
31 May 2002
TL;DR: In this article, an invention concerne an extrait d'Acanthopanax Senticosus de Coree, un extrait de proteine, un polysaccharide de proteina brut, which en sont derives, une composition de regulation immunitaire, and leur utilisation.
Abstract: La presente invention concerne un extrait d'Acanthopanax Senticosus de Coree, un extrait de proteine, un polysaccharide de proteine brut qui en sont derives, une composition de regulation immunitaire dont il est le principe actif, et leur utilisation. L'invention concerne plus particulierement de tels extraits et derives renforcant l'immunite, hautement efficaces contre les allergies et convenant de ce fait comme principes actifs d'aliments fonctionnels, de cosmetiques et de compositions pharmaceutiques. L'invention concerne enfin, d'une part une composition de regulation immunitaire dont ces extraits et derives constituent le principe actif, et d'autre part l'utilisation de cette composition.