Y
Young S. Lo
Researcher at DuPont
Publications - 37
Citations - 795
Young S. Lo is an academic researcher from DuPont. The author has contributed to research in topics: Aryl & Azetidine. The author has an hindex of 15, co-authored 37 publications receiving 776 citations. Previous affiliations of Young S. Lo include Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor
Michael E. Pierce,Rodney L. Parsons,Lilian A. Radesca,Young S. Lo,Stuart Silverman,James R. Moore,Q. Islam,Anusuya Choudhury,Joseph M. Fortunak,Dieu Nguyen,Chi Luo,Susan J. Morgan,Wayne P. Davis,Pat N. Confalone,Cheng-yi Chen,Richard D. Tillyer,Lisa F. Frey,Lushi Tan,Feng Xu,Dalian Zhao,Andrew S. Thompson,Edward G. Corley,Edward J. J. Grabowski,Robert A. Reamer,Paul J. Reider +24 more
TL;DR: In this article, a highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described, which proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) in excellent chemical and optical purity.
Journal ArticleDOI
Synthesis and physicochemical properties of sulfamate derivatives as topical antiglaucoma agents.
Young S. Lo,Joseph C. Nolan,Thomas H. Maren,William J. Welstead,David F. Gripshover,Dwight A. Shamblee +5 more
TL;DR: Sulfamic acid 2-[4-(1H-imidazol-1-yl)phenoxy]ethyl ester monohydrochloride (16) has the best combination of properties and showed excellent topical activity in lowering the intraocular pressure in New Zealand white rabbits.
Journal ArticleDOI
Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: synthesis and structure-activity relationships of a new series of H1 antihistamines.
Albert D. Cale,Thomas Gero,Kathleen R. Walker,Young S. Lo,William J. Welstead,Larry W. Jaques,Ashby F. Johnson,Charles A. Leonard,Joseph C. Nolan,David N. Johnson +9 more
TL;DR: A series of novel benzo- and pyrido-1,4-oxazepinones and -thiones which represents a new structural class of compounds possessing H1 antihistaminic activity was synthesized, and the SARs were evaluated.
Patent
Tetrazolylphenylboronic acid intermediates for the synthesis of aii receptor antagonists.
TL;DR: In this paper, a biphenyl tetrazolelphenylboronic acid (PTHB) was proposed as an angiotensin II receptor (AIIR) antagonist.
Patent
Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
Young S. Lo,Joseph C. Nolan,William J. Welstead,David A. Walsh,Dwight A. Shamblee,Ibrahim M. Uwaydah +5 more
TL;DR: In this article, a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base.