L
Lilian A. Radesca
Researcher at DuPont
Publications - 11
Citations - 357
Lilian A. Radesca is an academic researcher from DuPont. The author has contributed to research in topics: Reverse-transcriptase inhibitor & Diazomethane. The author has an hindex of 4, co-authored 11 publications receiving 339 citations. Previous affiliations of Lilian A. Radesca include The New School & Bristol-Myers Squibb.
Papers
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Journal ArticleDOI
Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor
Michael E. Pierce,Rodney L. Parsons,Lilian A. Radesca,Young S. Lo,Stuart Silverman,James R. Moore,Q. Islam,Anusuya Choudhury,Joseph M. Fortunak,Dieu Nguyen,Chi Luo,Susan J. Morgan,Wayne P. Davis,Pat N. Confalone,Cheng-yi Chen,Richard D. Tillyer,Lisa F. Frey,Lushi Tan,Feng Xu,Dalian Zhao,Andrew S. Thompson,Edward G. Corley,Edward J. J. Grabowski,Robert A. Reamer,Paul J. Reider +24 more
TL;DR: In this article, a highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described, which proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) in excellent chemical and optical purity.
Journal ArticleDOI
One-Carbon Chain Extension of Esters to α-Chloroketones: A Safer Route without Diazomethane
Dengjin Wang,Mark D. Schwinden,Lilian A. Radesca,Bharat P. Patel,David R. Kronenthal,Ming-Hsing Huang,William A. Nugent +6 more
TL;DR: In this paper, the reaction of a variety of methyl esters with dimethylsulfoxonium methylide at 0-25 degrees C affords the chain-extended beta-keto dimethyl sulfoxideonium ylides.
Journal ArticleDOI
Stereoselective process for a CCR3 antagonist
Tai-Yuen Yue,Douglas D. McLeod,Kevin B. Albertson,Steven R. Beck,Joerg Deerberg,Joseph M. Fortunak,William A. Nugent,Lilian A. Radesca,Liya Tang,Cathie Dong Xiang +9 more
TL;DR: In this article, a convergent, multikilogram, stereoselective synthesis of 1 is described, where a key fragment, (S)-3-(4-fluorobenzyl)piperidine (2) was synthesized from valerolactam in three steps using our recently discovered Ir−BDPP-catalyzed asymmetric hydrogenation.
Journal ArticleDOI
Synthesis of HIV-1 Reverse Transcriptase Inhibitor DMP 266
TL;DR: In this paper, DMP 266, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor was prepared in six steps starting from commercially available 4-chlorophenyl isocyanate.
Patent
Asymmetric synthesis of quinazolin-2-ones useful as hiv reverse transcriptase inhibitors
Rodney L. Parsons,Roberta L. Dorow,Akin H. Davulcu,Joseph M. Fortunak,Gregory D. Harris,Goss S. Kauffman,William A. Nugent,Lilian A. Radesca +7 more
TL;DR: In this paper, an asymmetric synthesis of quinazolin-2-ones that are useful as inhibitors of HIV reverse transcriptase is described. The synthesis is accomplished through the chiral ligand mediated addition of cyclopropylacetylide.