Y
Youren Tong
Researcher at Brigham and Women's Hospital
Publications - 1
Citations - 367
Youren Tong is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Binding site & Inclusion bodies. The author has an hindex of 1, co-authored 1 publications receiving 313 citations.
Papers
More filters
Journal ArticleDOI
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
R. Jeremy Nichols,Nicolas Dzamko,Nicholas A. Morrice,David G. Campbell,Maria Deak,Alban Ordureau,Thomas Macartney,Youren Tong,Jie Shen,Alan R. Prescott,Dario R. Alessi +10 more
TL;DR: The results suggest that mutation of Ser910 and/or Ser935 to disrupt 14-3-3 binding does not affect intrinsic protein kinase activity, but induces LRRK2 to accumulate within discrete cytoplasmic pools, perhaps resembling inclusion bodies.