Maria Deak

TL;DR: The results show that LKB1 functions as a master upstream protein kinase, regulating AMPK‐related kinases as well as AMPK, and may mediate the physiological effects of L KB1, including its tumour suppressor function.

TL;DR: It is suggested that MSK1 may mediate the growth‐factor and stress‐induced activation of CREB, and exclude a role for MAPK AP‐K1 and MAPKAP‐K2/3 in this process.

TL;DR: These results provide the first evidence that PINK1 is activated following Δψm depolarization and suggest that Pink1 directly phosphorylates and activates Parkin, and indicate that monitoring phosphorylation of Parkin at Ser65 and/or Pinks1 at Thr257 represent the first biomarkers for examining activity of the PINK 1-Parkin signalling pathway in vivo.

TL;DR: Human PDK1 is homologous to the Drosophila protein kinase DSTPK61, which has been implicated in the regulation of sex differentiation, oogenesis and spermatogenesis and is likely to mediate the activation of PKB by insulin or growth factors.

TL;DR: This study lays the foundation for future work to establish the phospholipid-binding specificities of these proteins in vivo, and their physiological role(s).