Y
Yu Wang
Researcher at National Institutes of Health
Publications - 3
Citations - 852
Yu Wang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Apoptosis & FADD. The author has an hindex of 3, co-authored 3 publications receiving 847 citations. Previous affiliations of Yu Wang include Thomas Jefferson University.
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Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
John Bertin,Robert C. Armstrong,Sabine Ottilie,David A. Martin,Yu Wang,Sean Banks,Guang-Hua Wang,Tatiana G. Senkevich,Emad S. Alnemri,Bernard Moss,Michael J. Lenardo,Kevin J. Tomaselli,Jeffrey I. Cohen +12 more
TL;DR: In this paper, equine herpesvirus type 2 E8 protein and molluscum contagiosum virus MC159 protein both show sequence similarity to the death effector domains (DEDs) of the Fas/TNFR1 signaling components FADD and caspase-8.
Journal ArticleDOI
FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis
Srinivasa M. Srinivasula,Manzoor Ahmad,Sabine Ottilie,Florencia Bullrich,Sean Banks,Yu Wang,Teresa Fernandes-Alnemri,Carlo M. Croce,Gerald Litwack,Kevin J. Tomaselli,Robert C. Armstrong,Emad S. Alnemri +11 more
TL;DR: Interestingly, FLAME-1 is recruited to the Fas receptor complex and can abrogate Fas/TNFR-induced apoptosis upon expression in FasL/tumor necrosis factor-sensitive MCF-7 cells, possibly by acting as a dominant-negative inhibitor.
Journal ArticleDOI
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses.
Guang-Hua Wang,John Bertin,Yu Wang,David A. Martin,Jin Wang,Kevin J. Tomaselli,Robert C. Armstrong,Jeffrey I. Cohen +7 more
TL;DR: BHV4 BORFE2 gene encodes a protein that inhibits Fas- and TNFR1-induced apoptosis and contains death effector domains (DEDs) and is a member of a family of DED-containing proteins that includes other gamma-2 herpesviruses, such as Kaposi's sarcoma-associated herpesv virus and herpesvirus saimiri.