https://pubs.rsc.org/en/content/articlepdf/2016/np/c6np00059b

Diterpenoids of terrestrial origin

Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds, terpinoids, etc. The use of the species in traditional and modern medicines is well known. For instance, V. jatamansi is very important for its insect repelling and antihelmethic properties. Similarly, sedative, neurotoxic, cytotoxic, antidepressant, antioxidant, and antimicrobial activities of the species in various ailments in the indigenous system of medicine, particularly in Asia, are reported. This review focuses on the detailed phytochemical composition, medicinal uses, and pharmacological properties of V. jatamansi along with analysis of botanical errors in published literature and reproducibility of the biomedical researches on this multipurpose herbaceous species.

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years.

Iridoids and sesquiterpenoids from the roots of Valeriana jatamansi Jones

Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells.

Three new iridoids, jatamanins N–P (1–3), along with the seven known iridiods 4–10, were isolated from the roots of Valeriana jatamansi. Compound 1 is an unusual iridoid bearing two epoxy bridges between C(3) and C(6) and between C(1) and C(10), forming a unique cage-like rigid skeleton. The structures of the new compounds were assigned on the basis of spectroscopic methods.

Iridoids from the Roots of Valeriana jatamansi

From the fruits of Pieris formosa, four new highly acylated 3,4-secograyanane diterpenoids, secorhodomollolides E–H (1–4, resp.), along with two known ones, secorhodomollolides C and D (5 and 6, resp.), were obtained. Their structures were established mainly by spectroscopic methods, including 1D- and 2D-NMR spectroscopy, and mass spectrometry.

Yuan-Dan Li

Papers

Iridoids from the Roots of Valeriana jatamansi

Highly Acylated 3,4-Secograyanane Diterpenoids from the Fruits of Pieris formosa