Y
Yuan Zhou
Researcher at Zhejiang University
Publications - 8
Citations - 398
Yuan Zhou is an academic researcher from Zhejiang University. The author has contributed to research in topics: Autophagy & PI3K/AKT/mTOR pathway. The author has an hindex of 6, co-authored 8 publications receiving 176 citations.
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Journal ArticleDOI
Blocking Triggering Receptor Expressed on Myeloid Cells‐1‐Positive Tumor‐Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti‐Programmed Cell Death Ligand 1 Resistance in Liver Cancer
Qinchuan Wu,Wuhua Zhou,Shengyong Yin,Yuan Zhou,Tianchi Chen,Junjie Qian,Rong Su,Hong Liangjie,H. Lu,Feng Zhang,Haiyang Xie,Lin Zhou,Shusen Zheng +12 more
TL;DR: It is highlighted that the hypoxic environment initiated the onset of tumor immunosuppression through TREM‐1+ TAMs attracting CCR6+Foxp3+ Tregs, and TREM-1- TAMs endowed HCC with anti‐PD‐L1 therapy resistance.
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YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway
Yuan Zhou,Yubo Wang,Wuhua Zhou,Tianchi Chen,Qinchuan Wu,Vikram Kumar Chutturghoon,Bingyi Lin,Lei Geng,Zhe Yang,Lin Zhou,Shusen Zheng +10 more
TL;DR: The findings suggested that YAP upregulation endowed HCC cells with multi-drug resistance via the RAC1-ROS-mTOR pathway, resulting in the repression of autophagy-related cell death.
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Integrated analysis of microbiome and host transcriptome reveals correlations between gut microbiota and clinical outcomes in HBV-related hepatocellular carcinoma.
Hechen Huang,Zhigang Ren,Zhigang Ren,Xingxing Gao,Xiaoyi Hu,Yuan Zhou,Jianwen Jiang,Haifeng Lu,Shengyong Yin,Junfang Ji,Lin Zhou,Shusen Zheng +11 more
TL;DR: It is revealed that changes in tumor immune microenvironment caused by the gut microbiota via serum bile acids may be important factors associated with tumor burden and adverse clinical outcome.
Journal ArticleDOI
HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways
TL;DR: The data revealed that HJURP is an oncogene that drives cell cycle progression upstream of p21 in HCC, and may provide a potential therapeutic and prognostic target for HCC.
Journal ArticleDOI
PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
Wuhua Zhou,Li Gong,Qinchuan Wu,Chunyang Xing,Bajin Wei,Tianchi Chen,Yuan Zhou,Shengyong Yin,Bin Jiang,Haiyang Xie,Lin Zhou,Shusen Zheng +11 more
TL;DR: Findings suggested that PHF8 played an oncogenic role in facilitating FIP200-dependent autophagic degradation of E-cadherin, EMT and metastasis in HCC and might be a promising target for prevention, treatment and prognostic prediction of HCC.