Yudong Ren

TL;DR: PEDV structural proteins found that PEDV nucleocapsid protein (N) could activate NF-κB and that the central region of N was essential for NF-σκB activation, provide new avenues of investigation into the molecular mechanisms of NF-γB activation induced by P EDV infection.

TL;DR: PEDV infection of its target cell line, IECs, inhibited dsRNA-mediated IFN-β production by blocking the activation of IPS-1 in RIG-I-mediated pathway, and offered new visions in understanding of the interaction between PEDV and host innate immune system.

TL;DR: It is demonstrated that HPE had significant anti-IBV effects in vitro and in vivo, respectively, and it is possible owing to up-regulate mRNA expression of type I interferon through the MDA5 signaling pathway and down-regulates mRNAexpression of IL-6 and TNF-α via the NF-κB signaling pathway.

TL;DR: The results showed that the recombinant DNA plasmids increased the proliferation of T lymphocytes and the number of CD4+ and CD8+ T lymphocyte subgroups and stimulated higher levels of specific antibodies and neutralizing antibodies in immunized mice.

TL;DR: The antibody produced in this study was capable of detecting the cell infection by PRRSV and distinguishing this virus from other viruses.