Showing papers by "Yuji Miyahara published in 1995"

Analyzer having sensor with memory device

Abstract: An analyzer includes an exchangeable and consumable element such as a sensor, column or reagent the characteristic of which specifies an analyzing condition. The element is provided with a non-volatile semiconductor memory which holds an analyzing condition adapted for the element as data. When the element is mounted on an analyzer body, a controller of the analyzer reads the analyzing condition from the memory to update an analyzing condition inherently provided in the analyzer body. The result of analysis and/or operational history information of use of the element may be written into the memory with which the element is provided.

Method and equipment for optoacoustic analysis

Abstract: PROBLEM TO BE SOLVED: To obtain a small and highly accurate optoacoustic analyzer and analyzing method. SOLUTION: An acoustic impedance matching layer 8 transparent for the light from a light source 1 is interposed between a reference sample 9 and a measuring sample 10 and only one acoustic sensor 12 is disposed while touching the measuring sample 10. A pulse light from the light source 1 is passed simultaneously through the reference sample 9, acoustic impedance matching layer 8 and measuring sample 10. Sound waves from the reference sample 9 and measuring sample 10 are detected using one acoustic sensor 12 while being separated on the time axis.

Photo-acoustic analyzer

Abstract: PROBLEM TO BE SOLVED: To obtain a photo-acoustic analyzer in which a plurality of measurements can be made repeatedly in a short time by irradiating a specimen with a plurality of monochromic lights subjected to amplitude modification by reference signals having different carrier frequency. SOLUTION: In order to detect the concentration of a light absorbing substance in a specimen, the specimen is irradiated with a plurality of monochromic lights having different wavelength. The monochromic lights are subjected to amplitude modification by reference signals having different carrier frequency. Furthermore, sound waves produced through photo-acoustic effect are demodulated by the difference carrier frequencies. More specifically, lasers 112, 113 oscillate lights of wavelength λ1, λ2 which are subjected to intensity modulation by optical modulators 120, 121 according to reference signals 204, 205. An organism 150 is irradiated simultaneously with these lights. The absorption of light takes place in the organism 150 and a pressure wave is generated through volume expansion caused thereby. The pressure wave is converted through a piezoelectric element 171 and an acoustic coupler 172 into an electric signal which is fed through an amplifier 18 to demodulation circuits 181, 182 and demodulated.

Transannular Interactions in Fluorine-substituted [3.3]Metacyclophanes

Abstract: Effects of fluorine substituents on transannular interaction in [3.3]metacyclophanes were examined on the basis of chemical and spectral properties of five [3.3]metacyclophanes possessing one or two fluorine atoms at the inner and/or outer positions.

Biochemical analysis device

Abstract: PURPOSE: To measure enzyme activity via the infrared spectroscopic method by immobilizing a substrate to the surface of an attenuated total reflection prism directly or indirectly. CONSTITUTION: A substrate is immobilized directly or indirectly to the surface of an attenuated total reflection prism 1, and a sample 4 is introduced to start reaction between the substrate and enzyme contained in the sample 4, thereby obtaining two infrared absorption spectra in different reaction time per sample. Then, the concentration change of the substrate or an enzyme reaction product in the sample 4 per unit time is calculated from the spectra, thereby measuring enzyme activity in the sample 4.

Photo-acoustic spectroscopy and spectrometer

Abstract: PROBLEM TO BE SOLVED: To prevent the sensitivity from lowering due to the phase difference or interference caused by the difference between the irradiating position of exciting light and each point at the sensitive part of a sensor by irradiating a sample with an exciting light while scanning at a rate higher than the sound velocity. SOLUTION: A sample 4 is irradiated intermittently with a light of such wavelength as being absorbed by an object emitted from a light source 1. A beam splitter 2 introduces a part thereof to an optical scanner 3 which then irradiates the sample 4 with an exciting light while scanning at a rate higher than the sound velocity. Consequently, a substance in the sample 4 absorbs the light and excited. When the absorbed energy is discharged, displacement takes place through thermal expansion thus generating a photo-acoustic wave. It is detected by a piezoelectric sensor 5 having a planar sensitive part touching the sample 4 and converted into an electric signal. The electric signal is amplified through an amplifier 6 and subjected to analysis and determination by a metric controller 8 thus producing a signal proportional to the quantity of substance to be measured in the sample 4. COPYRIGHT: (C)1997,JPO

Analysing system for e.g. automatic blood analysis

Abstract: The analysing system involves a sampling mechanism, a magnetic valve and a solution supply mechanism working in conjunction with the control unit (8), for processing e.g. a blood sample, based on the read-out analysing conditions. The control unit gives the analysis result. A sensor system (2) e.g. a chromatography column has a removably attachable measurement sensor (10) which has a characteristic which is determined from the analysing conditions for the sample. It has a non-volatile memory unit (11), which is fed the analysing conditions determined by the sensor, and/or stores the analysis result.

Quantitative analysis of multiple component substance

Abstract: PURPOSE:To quantitatively analyze multiple components highly correctly by simulating a response of a mixture through a combined operation of predicted responses of single components obtained by operations and using the response as a reference data. CONSTITUTION:An optional component in a mixed aqueous solution is indicated by (i). K aqueous solutions of different concentrations are obtained as reference substances by dissolving only the (i) component. The infrared spctrum of each reference substance is measured. On the other hand, the concentration composition of components of a reference data directly used for calibration is calculated. Then, (i) sequences of the absorbance of components corresponding to the concentration composition of the reference data I are added, which is an absorbance sequence of the reference data I. The calculated one reference data is formed into a sequence. A regression expression for calibration is obtained by processing this sequence and the sequence of the concentration of components regressively. A sequence of the absorbance of a sample is formed by measuring the infrared spectrum of the sample and expressing the spectrum in a sequence. A predicted concentration is calculated by substituting the sequence of the absorbance of the sample in the regression expression.

Total reflection prism cell

Abstract: PURPOSE:To measure the infrared absorption spectrum of a liquid sample with high sensitivity by disposing a mesh metal carrying a sample under a prism. CONSTITUTION:A gold mesh 3(mesh metal) of 100pm thick is set under a semicylindrical total reflection prism 1 through an air gap of 20mum. A liquid sample 5 is then injected through an injection port 6 into the gold mesh 3 using a syringe 7. Infrared light 8 enters the end face of the prism 1 and partially reflected on the interface of the prism 1 and the air gap 2 while partially transmits the interface. The light impinging directly on the gold mesh 3 through the air gap 2 excites the local field on the surface of gold and increases the infrared absorption of the sample 5 at a part in contact with the excited part of gold mesh 3. The light impinging on the gold mesh 3 through the sample 5 is confined within a cavity defined by the gold mesh 3 and produces an interference field thus increasing infrared absorption of the sample 5 in the cavity.

Solid ion sensor

Abstract: PURPOSE:To provide a solid ion sensor which requires no internal electrolyte, and is excellent in stability, and also a solid ion sensor showing the electrode potential equal to an ion electrode having the internal electrolyte CONSTITUTION:An ion sensitive film 2 and a hydrophilic polymer film 3 in which a hydrophilic electrolyte consisting of a target ion or halogen ion or an electrolyte consisting of an ion other than the target ion or halogen ion is dispersed by the contact with an electrode 4 consisting of a metal and its halide are provided in such a manner that the weight ratio of the electrolyte to the polymer [(electrolyte) wt%/(polymer) wt%] is 1/100 or more

Reduction of glucose interference in biochemical analyses based on infrared spectroscopy

Abstract: 減衰全反射プリズムを用いた赤外分光法による生化学分析において,試料中グルコースが他の生化学成分の測定に与える干渉の低減について検討した.まず人工的に合成したグルコースと尿素の混合水溶液のスペクトルを用い,尿素濃度測定へのグルコースの干渉をシミュレーションにより検討し,校正条件の最適化により干渉が低減することを明らかにした.基礎検討に基づいて最適化した校正条件の下でヒト血清中生化学成分の定量分析を行った結果,トリグリセリド,尿素,コレステロール,尿酸,クレアチニンの測定に対するグルコースの干渉を低減することができた.又,総タンパク質,グルコース,トリグリセリド,コレステロール,尿素の測定では,自動分析装置との良好な相関が得られた.