Yulia V. Lyupina

TL;DR: Addition of KNK437, a known inhibitor of inducible HSPs, decreased the rate of viral DNA synthesis in infected cells more than one order of magnitude and markedly suppressed the release of budded viruses indicating the importance of the heat shock response for baculovirus replication.

TL;DR: Eight members of the HSP/HSC70 family were identified in Spodoptera frugiperda Sf9 cells infected with AcMNPV by 2D electrophoresis followed by mass spectrometry and a Mascot search, suggesting a supportive role of HSP90 in virus replication.

TL;DR: This article showed that brain-derived proteasomes from mice with experimental encephalomyelitis (EAE) in an ubiquitin-independent manner generate significantly increased amounts of myelin basic protein peptides that induces cytotoxic lymphocytes to target mature oligodendrocytes ex vivo.

TL;DR: It is shown that brain‐derived proteasomes from SJL mice with experimental autoimmune encephalomyelitis (EAE) in an ubiquitin‐independent manner generate significantly increased amounts of myelin basic protein peptides that induces cytotoxic lymphocytes to target mature oligodendrocytes ex vivo.

TL;DR: Breast cancer development is connected with functioning of immune proteasome forms and activator PA700 in patients without estrogen α-receptors in tumor cells, which could indicate a field for search of new therapy approaches for this category of patients, which has the worst prognosis of health recovery.