Yun Hu

TL;DR: Investigation of physicochemical properties of binary amorphous dispersions of poorly soluble sulfonamide/polymeric excipient prepared by ball milling revealed that dispersions remained dry and powdery compared to those made with PVP that formed a sticky paste in less than 2 weeks, indicating a possible advantage of using Soluplus® in terms of increased physical stability under high humidity storage conditions.

TL;DR: In this article, the anhydrous solvent-free mechanochemical reaction of sulfathiazole, STZ, polymorphs I, III, and V with 10 carboxylic acids was monitored by powder X-ray diffraction (PXRD), attenuated total reflectance infrared (ATR-IR), and near-infrared (NIR) spectroscopy.

TL;DR: NIR spectroscopy exhibits the smallest analytical error, higher accuracy and robustness and when these advantages are combined with the greater convenience of NIR's "in glass bottle" sampling method both ATR-IR and Raman methods appear less attractive.

TL;DR: The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this polymorphic mixture of piracetam, making PXRD the least preferred method of quantification.

TL;DR: The Oscail software package as mentioned in this paper provides attachment energy calculations, crystal surface analysis, and crystal visualization for flat π-stacking systems, which can be used to identify the density of available hydrogen bond donors and acceptors on crystal faces.