Yuzuru Ishimura

TL;DR: It is reported that the Asp-51 → Asn mutation of the bovine enzyme abolishes its proton-pumping function without impairment of the dioxygen reduction activity.

TL;DR: Results indicate that induction of the HO-1 activity serves as a potential stratagem to prevent oxidant-induced microvascular leukocyte adhesion through the action of bilirubin, a product of HO reaction.

TL;DR: Site-directed mutants of cytochrome P-450cam, in which threonine-252 had been changed to alanine, valine, or serine, were employed to study the role of the hydroxy amino acid in the monooxygenase reaction, exhibited optical absorption spectra almost indistinguishable from those of the wild-type enzyme in their ferric, ferrous, oxygenated, and carbon monoxide ferrous forms.

TL;DR: It is suggested that CO evolved by HO-2 in the parenchymal cells, and, released to the extrasinusoidal space, served as the physiological relaxant for hepatic sinusoids.

TL;DR: TPA switched a suicide process induced by A23187 to an opposite process: stimulation of DNA synthesis, suggesting that the signals by protein kinases and calcium ions may regulate both cell proliferation and death, independently, synergistically or antagonistically.