Yves Garnier

TL;DR: Perinatal brain damage in the mature fetus is usually brought about by severe intrauterine asphyxia following an acute reduction of the uterine or umbilical circulation, thought to be caused by the post-ischemic release of oxygen radicals, synthesis of nitric oxide, inflammatory reactions and an imbalance between the excitatory and inhibitory neurotransmitter systems.

TL;DR: This review will focus on the dynamic changes of the fetal circulation, the distribution of organ blood flow during normoxemia, and that during hypoxia and asphyxia caused by various experimental perturbations.

TL;DR: Interestingly, the presence of chorioamnionitis is associated with a lower rate of neonatal mortality in extremely immature newborns, and the concept of fetal multiorganic disease during intrauterine infection is introduced and discussed.

TL;DR: There is increasing evidence from recent clinical studies that perinatal brain damage is closely associated with ascending intrauterine infection before or during birth, and a major part of this damage is likely to be of hypoxic-ischemic nature due to LPS-induced effects on fetal cerebral circulation.

TL;DR: It is suggested that both prematurity and inflammation in utero disturb fetal gut development, potentially predisposing to postnatal intestinal pathology and are further compromised by endotoxin-induced chorioamnionitis.