Journal ArticleDOI
Dynamics of fetal circulatory responses to hypoxia and asphyxia.
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TLDR
This review will focus on the dynamic changes of the fetal circulation, the distribution of organ blood flow during normoxemia, and that during hypoxia and asphyxia caused by various experimental perturbations.About:
This article is published in European Journal of Obstetrics & Gynecology and Reproductive Biology.The article was published on 1999-06-01. It has received 180 citations till now. The article focuses on the topics: Asphyxia & Fetal circulation.read more
Citations
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Journal ArticleDOI
Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy.
TL;DR: Mod was present in all the infants with severe post-asphyxial HIE, however, there was no association between MOD and outcome in these infants, and no relation between individual or combinations of organ involvements and long term outcomes was observed.
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Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges
TL;DR: Neonatal hypoxia-ischaemia is examined, evidence for the relevance of subplate-secreted molecules to this condition is reviewed, and Neuroserpin, a neuronally released neuroprotective factor, is discussed as a case study for developing new potential pharmacological interventions for use post- ischaemic injury.
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Hypoxia and fetal heart development.
Andrew J. Patterson,Lubo Zhang +1 more
TL;DR: The altered expression pattern of cardioprotective genes such as protein kinase c epsilon, heat shock protein 70, and endothelial nitric oxide synthase, likely predispose the developing heart to increased vulnerability to ischemia and reperfusion injury later in life.
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Fetal hypoxia insults and patterns of brain injury: Insights from animal models
Alistair J. Gunn,Laura Bennet +1 more
TL;DR: The multiple factors that modify the risk of injury are dissected, including the depth ('severity'), duration, and repetition of the insult, the maturity, and condition of the fetus, pre-existing hypoxia, and exposure to pyrexia and infection/inflammation.
References
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Journal ArticleDOI
The Circulation of the Fetus in Utero METHODS FOR STUDYING DISTRIBUTION OF BLOOD FLOW, CARDIAC OUTPUT AND ORGAN BLOOD FLOW
TL;DR: Experimental evidence is provided that (1) there is no significant recirculation of microspheres, (2) the distribution of spheres is proportional to flow, and (3) circulatory physiology is not altered by injection of spheres.
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Cardiovascular responses to hypoxemia and acidemia in fetal lambs.
TL;DR: The studies quantitate the fetal circulatory changes that occur in unanesthetized fetal lambs in utero during maternal hypoxemia and acidemia.
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Respiratory movements and rapid eye movement sleep in the foetal lamb
TL;DR: In foetal lambs from 40 days gestation (0·27 of term) onwards delivered into a warm saline bath, apparently spontaneous breathing movements were present intermittently and became deeper and more rapid with increasing age.