Y
Yves Guichard
Researcher at Institut national de la recherche scientifique
Publications - 16
Citations - 363
Yves Guichard is an academic researcher from Institut national de la recherche scientifique. The author has contributed to research in topics: Genotoxicity & Micronucleus test. The author has an hindex of 9, co-authored 16 publications receiving 295 citations. Previous affiliations of Yves Guichard include Institut national de recherche et de sécurité.
Papers
More filters
Journal ArticleDOI
Cytotoxicity and genotoxicity of nanosized and microsized titanium dioxide and iron oxide particles in Syrian hamster embryo cells.
Yves Guichard,Julien Schmit,Christian Darne,Laurent Gaté,Michèle Goutet,Davy Rousset,Olivier Rastoix,Richard Wrobel,Olivier Witschger,Aurélie Martin,Vanessa Fierro,Stéphane Binet +11 more
TL;DR: It is suggested that in vitro cytotoxicity and genotoxicity induced by metal oxide nanoparticles are not always higher than those induced by their bulk counterparts.
Journal ArticleDOI
Iron oxide particles modulate the ovalbumin-induced Th2 immune response in mice.
TL;DR: It is demonstrated that the pulmonary immune response to OVA is a sensitive target for intratracheally instilled particles, depending on the particle dose and size, the allergic response was suppressed or enhanced.
Journal ArticleDOI
Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and intravenous injection
Yves Guichard,Marie-Aline Maire,Sylvie Sébillaud,Caroline Fontana,Cristina Langlais,Jean-Claude Micillino,Christian Darne,Joanna Roszak,Maciej Stępnik,Valérie Fessard,Stéphane Binet,Laurent Gaté +11 more
TL;DR: It was concluded that under experimental conditions, SAS induced obvious toxic effects but did not cause any genotoxicity following intratracheal instillation and intravenous injection.
Journal ArticleDOI
Cytotoxic and genotoxic evaluation of different synthetic amorphous silica nanomaterials in the V79 cell line.
Yves Guichard,Caroline Fontana,E Chavinier,F. Terzetti,Laurent Gaté,Stéphane Binet,Christian Darne +6 more
TL;DR: Overall, the results of this study show that pyrogenic, precipitated and colloidal manufactured SAS of around 20 nm primary particle size can produce significant cytotoxic and genotoxic effects in V79 cells, despite having been manufactured by same processes as their finer-grained equivalents.
Journal ArticleDOI
Epigenetic changes in the early stage of silica-induced cell transformation.
Carole Seidel,Anaïs Kirsch,Caroline Fontana,Athanase Visvikis,Aurélie Remy,Laurent Gaté,Christian Darne,Yves Guichard +7 more
TL;DR: Both types of particle treatment induced strong c-Myc expression in the early stage of cell transformation and this correlated with enrichment in RNA polymerase II as well as histone active marks on its promoter suggesting their involvement mainly in the first steps of cell Transformation.