L
Laurent Gaté
Researcher at Institut national de recherche et de sécurité
Publications - 31
Citations - 656
Laurent Gaté is an academic researcher from Institut national de recherche et de sécurité. The author has contributed to research in topics: Inhalation exposure & Chemistry. The author has an hindex of 11, co-authored 26 publications receiving 435 citations. Previous affiliations of Laurent Gaté include Institut national de la recherche scientifique.
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Journal ArticleDOI
Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale
Sabina Halappanavar,Sybille van den Brule,Penny Nymark,Laurent Gaté,Carole Seidel,Sarah Valentino,Vadim Zhernovkov,Pernille Høgh Danielsen,Andrea De Vizcaya,Andrea De Vizcaya,Henrik Wolff,Tobias Stöger,Andrey Boyadziev,Sarah S. Poulsen,Jorid B. Sørli,Ulla Vogel +15 more
TL;DR: A brief overview of the AOP framework and its application to nanotoxicology, tools for developing AOPs and the role of toxicogenomics are detailed, and various AOP's of relevance to inhalation toxicity of nanomaterials that are currently under various stages of development are summarized.
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Cytotoxicity and genotoxicity of nanosized and microsized titanium dioxide and iron oxide particles in Syrian hamster embryo cells.
Yves Guichard,Julien Schmit,Christian Darne,Laurent Gaté,Michèle Goutet,Davy Rousset,Olivier Rastoix,Richard Wrobel,Olivier Witschger,Aurélie Martin,Vanessa Fierro,Stéphane Binet +11 more
TL;DR: It is suggested that in vitro cytotoxicity and genotoxicity induced by metal oxide nanoparticles are not always higher than those induced by their bulk counterparts.
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Brain Inflammation, Blood Brain Barrier dysfunction and Neuronal Synaptophysin Decrease after Inhalation Exposure to Titanium Dioxide Nano-aerosol in Aging Rats.
Clémence Disdier,Monique Chalansonnet,F. Gagnaire,Laurent Gaté,Frédéric Cosnier,Jérôme Devoy,Wadad Saba,Amie K. Lund,Emilie Brun,Aloïse Mabondzo +9 more
TL;DR: An association between the exposure to TiO2 NPs and the dysregulation of BBB physiology associated with neuroinflammation and decreased expression of neuronal activity marker, which was further exacerbated in the brain of aged animal’s is observed.
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Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and intravenous injection
Yves Guichard,Marie-Aline Maire,Sylvie Sébillaud,Caroline Fontana,Cristina Langlais,Jean-Claude Micillino,Christian Darne,Joanna Roszak,Maciej Stępnik,Valérie Fessard,Stéphane Binet,Laurent Gaté +11 more
TL;DR: It was concluded that under experimental conditions, SAS induced obvious toxic effects but did not cause any genotoxicity following intratracheal instillation and intravenous injection.
Journal ArticleDOI
Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats.
Laurent Gaté,Clémence Disdier,Frédéric Cosnier,F. Gagnaire,Jérôme Devoy,Wadad Saba,Emilie Brun,Monique Chalansonnet,Aloïse Mabondzo +8 more
TL;DR: The biodistribution of titanium in healthy young adults and in elderly rats exposed to 10mg/m3 of a TiO2 nanostructured aerosol 6h/day, 5days/week for 4 weeks is reported, suggesting thatTiO2 NPs may translocate from the lung to extra-pulmonary organs where they could possibly promote systemic health effects.