Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.

Use of inhibitors of bruton's tyrosine kinase (Btk)

Hole-cleaning performance comparison of oil-based and water-based drilling fluids

Viscoelastic properties of drilling fluids and their influence on cuttings transport

Hole cleaning and drilling fluid sweeps in horizontal and deviated wells: Comprehensive review

Described herein are methods and compositions comprising a covalent TEC family kinase inhibitor for use in adjuvant therapy, including adjuvant cancer therapy, vaccination and treatment of immune disorders and pathogenic infections

Tec family kinase inhibitor adjuvant therapy

One important requirement for a drilling fluid is the ability to transport the cuttings out of the borehole. Improved hole cleaning is a key to solve several challenges in the drilling industry and will allow both longer wells and improved quality of well construction. It has been observed, however, that drilling fluids with similar properties according to the API standard can have significantly different behavior with respect to hole cleaning performance. The reasons for this are not fully understood.This paper presents results from laboratory tests where water based drilling fluids with similar rheological properties according to API measurements have been tested for their hole cleaning capabilities in a full scale flow loop. Thorough investigation of the viscoelastic properties of the fluids were performed with, among other instruments, a Paar-Physica rheometer.Improved understanding of the fluid properties relevant to hole cleaning performance will help develop better models of wellbore hydraulics used in planning of well operations. Eventually this may lead to higher ROP with water based drilling fluids as obtained with oil based drilling fluids. This may ease cuttings handling in many operations and thereby significantly reduce the drilling cost using (normally) more environmentally friendly fluids.The experiments have been conducted as part of an industry-sponsored research project where understanding the hole cleaning performance of various oil and water based drilling fluids is the aim. The experiments have been performed under realistic conditions. The flow loop includes a 12 meter long test section with 2″ OD freely rotating drillstring inside a 4″ ID wellbore made of concrete. Sand particles were injected while circulating the drilling fluid through the test section in horizontal position.Copyright © 2014 by ASME

Experimental Study of Cuttings Transport Efficiency of Water Based Drilling Fluids

Field Application of an Innovative, Minimally Damaging Low-ECD Invert Emulsion Fluid for Drilling and Completion of HP/HT Wells: Update on Fluid Performance

Experimental Investigation of Cuttings Transport With Oil Based Drilling Fluids

Innovative Test Solutions of Drilling & Completion Fluids to Maximize Well Productivity

The present invention provides a test cell for assessing a well fluid comprising: a body, an inlet means and an outlet means; a formation sample shaped to fit inside said body; and a screen sample shaped to fit inside said body.

Zalpato Ibragimova

Papers

Experimental Study of Cuttings Transport Efficiency of Water Based Drilling Fluids

Field Application of an Innovative, Minimally Damaging Low-ECD Invert Emulsion Fluid for Drilling and Completion of HP/HT Wells: Update on Fluid Performance

Experimental Investigation of Cuttings Transport With Oil Based Drilling Fluids

Innovative Test Solutions of Drilling & Completion Fluids to Maximize Well Productivity

Test cell for assessing a well fluid