Zeng-Ping Kang

TL;DR: It is suggested that curcumin ameliorated colitis by regulating DCs, Treg and gut microbiota, and the underlying mechanism is related to PI3K/Akt pathway inhibition.

TL;DR: Curcumin is a natural compound shown to be effective against human inflammatory bowel disease and experimental colitis, but the underlying mechanism is unclear as discussed by the authors, but it has been shown that curcumin significantly inhibited the activation of the JAK1/STAT5 signaling pathway, downregulation of JAK 1, STAT5, and p-STAT5 proteins in colon tissue, and upregulation of PIAS1 proteins.

TL;DR: Collectively, curcumin effectively alleviated colitis in mice with type 2 diabetes mellitus by restoring the homeostasis of Th17/Treg and improving the composition of the intestinal microbiota.

TL;DR: Panax ginseng has been found to have anti-inflammatory and immunomodulatory effects on IBD, including regulating the balance of immune cells, inhibiting the expression of cytokines, as well as activating Toll-like receptor 4, Nuclear factor-kappa B (NF-κB), nucleotide-binding oligomerization domain like receptor (NLRP), mitogen-activated protein kinase signaling, and so on as mentioned in this paper.

TL;DR: In this paper, a dextran sulfate sodium (DSS) model was used to model colitis and curcumin was administered to colitis mice for 14 consecutive days, and the concentration of proinflammatory cytokines IL-1β, IL-6, and CCL-2 in the colonic tissues decreased significantly while anti-inflammatory cytokine IL-33 and IL-10 increased significantly.