Z
Zhe Chen
Researcher at Shanghai Jiao Tong University
Publications - 26
Citations - 475
Zhe Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Propionibacterium acnes. The author has an hindex of 9, co-authored 17 publications receiving 294 citations.
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Journal ArticleDOI
Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway.
Yazhou Lin,Yucheng Jiao,Ye Yuan,Zezhu Zhou,Yuehuan Zheng,Jiaqi Xiao,Changwei Li,Zhe Chen,Peng Cao +8 more
TL;DR: Analysis of pathological changes in degenerated human intervertebral discs infected with Propionibacterium acnes provided evidence that P. acnes-induced apoptosis of NPCs via the TLR2/JNK pathway is likely responsible for the pathology of IVDD.
Journal ArticleDOI
Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.
Zhe Chen,Jonghyuck Park,Breanne Butler,Glen Acosta,Sasha Vega-Alvarez,Lingxing Zheng,Jonathan Tang,Robyn R. McCain,Wenpeng Zhang,Zheng Ouyang,Peng Cao,Riyi Shi +11 more
TL;DR: Phenelzine may be an effective treatment for neuropathic pain after SCI and likely a viable alternative to hydralazine, and its possible role of alleviating sensory hypersensitivity through acrolein suppression is investigated.
Journal ArticleDOI
Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.
Jonghyuck Park,Lingxing Zheng,Glen Acosta,Sasha Vega-Alvarez,Zhe Chen,Breanne Muratori,Peng Cao,Riyi Shi +7 more
TL;DR: It is shown that, post‐SCI elevation of TRPA1 mRNA exists not only in dorsal root ganglias but also in both peripheral (paw skin) and central endings of primary afferent nerves (dorsal horn of spinal cord), the first indication that pain signaling can be over‐amplified in the peripheral skin by elevated expressions ofTRPA1 following SCI.
Journal ArticleDOI
Association between chronic inflammation and latent infection of Propionibacterium acnes in non-pyogenic degenerated intervertebral discs: a pilot study.
Ye Yuan,Yong Chen,Zezhu Zhou,Yucheng Jiao,Changwei Li,Yuehuan Zheng,Yazhou Lin,Jiaqi Xiao,Zhe Chen,Peng Cao +9 more
TL;DR: Latent P. acnes infection was associated with chronic inflammation in degenerated intervertebral discs, especially in the samples with visible bacteria in histology, which manifested as increased numbers of cytokines and neutrophils.
Journal ArticleDOI
Propionibacterium acnes Induces Intervertebral Disc Degeneration by Promoting iNOS/NO and COX-2/PGE2 Activation via the ROS-Dependent NF-κB Pathway.
Yazhou Lin,Guoqing Tang,Yucheng Jiao,Ye Yuan,Yuehuan Zheng,Yong Chen,Jiaqi Xiao,Changwei Li,Zhe Chen,Peng Cao +9 more
TL;DR: quantified the severity of IVDD, as well as the expressions of inducible nitric oxide synthase (iNOS)/nitric oxide (NO) and cyclooxygenase (COX-2)/prostaglandin (PGE2) in human intervertebral disc degeneration infected with P. acnes, and found that the upregulation of iNOS/NO and COX- 2/PGE 2 was essential to the occurrence of P