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Showing papers by "Zhen Li published in 1995"

Journal Article•DOI•
A new immune escape mutant of hepatitis B virus with an Asp to Ala substitution in aa144 of the envelope major protein

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F. Ni1, D. Fang1, R. Gan1, Zhen Li1, S. Duan2, Z. Xu2 •
Academia Sinica1, Fudan University Shanghai Medical College2
01 Nov 1995-Research in Virology
TL;DR: The HBV mutant with envelope major protein144Asp-->Ala was shown to be a new immune escape variant, and two expression plasmids, pExpW and pExpM, were constructed and HBsAgs were expressed in COS-M6 cells.

35 citations

Journal Article•DOI•
Synthesis of spiro[4.4]nonane-1,6-diols via the hydrogenation of spiro[4.4]nonane-1,6-dione: the profound effect of hydrogenating agents

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Albert S. C. Chan1, Chi-Ching Lin1, Jian Sun2, Wenhao Hu2, Zhen Li2, Weidong Pan2, Aiqiao Mi2, Yaozhong Jiang2, Tsang-Miao Huang3, Teng-Kuei Yang3, Jyh-Horung Chen3, Yu Wang4, Gene-Hsiang Lee4 •
Hong Kong Polytechnic University1, Chinese Academy of Sciences2, National Chung Hsing University3, National Taiwan University4
01 Dec 1995-Tetrahedron-asymmetry
TL;DR: In this paper, the synthesis of spiro[4.4]nonane-1,6-diols via the catalytic as well as stoichiometric hydrogenation was studied, and the effects of the hydrogenation catalysts and reagents on the stereoselectivity of the products were observed.
Abstract: The synthesis of spiro[4.4]nonane-1,6-diols via the catalytic as well as stoichiometric hydrogenation of spiro[4.4]nonane-1,6-dione was studied. Profound effects of the hydrogenation catalysts and reagents on the stereoselectivity of the products were observed. The choice of solvent also was found to have a significant influence on the product selectivity. The opening of a spiro-ring in the starting material was identified as a major side reaction in alcohol solvents. The absolute configuration of the trans, trans-diol was unambiguously determined by X-ray crystallography.

20 citations