Z
Zheng-Sheng Ye
Researcher at Massachusetts Institute of Technology
Publications - 7
Citations - 1523
Zheng-Sheng Ye is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & SH3 domain. The author has an hindex of 7, co-authored 7 publications receiving 1515 citations. Previous affiliations of Zheng-Sheng Ye include Rockefeller University.
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Involvement of CRAF1, a relative of TRAF, in CD40 signaling
TL;DR: A yeast two-hybrid screen identified a gene, CRAF1, encoding a protein that interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors.
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Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.
TL;DR: The association of Crk and Abl suggests that Abl could play a role in v-Crk and Crk-I transformation and that normal Abl function may be partly mediated through bound adapter molecules.
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Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.
TL;DR: Oct-2 is not required for the generation of immunoglobulin-bearing B cells but is crucial for their maturation to immunoglOBulin-secreting cells and for another undetermined organismal function.
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Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction
TL;DR: It is shown that Btk interacts with Src homology 3 domains of Fyn, Lyn, and Hck, protein-tyrosine kinases that get activated upon stimulation of B- and T-cell receptors, mediated by two 10-aa motifs in Btk.
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RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.
TL;DR: By the use of the two-hybrid protein interaction system, a human protein that specifically interacts with RAG-1 is isolated, which is the human homologue of the yeast SRP1 (suppressor of a temperature-sensitive RNA polymerase I mutation).