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Patricia Cortes
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 38
Citations - 2668
Patricia Cortes is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: V(D)J recombination & RAG2. The author has an hindex of 27, co-authored 36 publications receiving 2565 citations. Previous affiliations of Patricia Cortes include Mount Sinai Hospital & Austral University of Chile.
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Journal ArticleDOI
V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations.
Anna Villa,Cristina Sobacchi,Luigi D. Notarangelo,Fabio Bozzi,Mario Abinun,Tore G. Abrahamsen,Peter D. Arkwright,Michal Baniyash,Edward G. Brooks,Mary Ellen Conley,Patricia Cortes,Marzia Duse,Anders Fasth,Alexandra M. Filipovich,Anthony J. Infante,Alison L Jones,Evelina Mazzolari,Susanna M. Müller,Srdjan Pasic,Gideon Rechavi,Maria Grazia Sacco,Sandro Santagata,Marlis L. Schroeder,Reinhard Seger,Dario Strina,Alberto G. Ugazio,Jouni Väliaho,Mauno Vihinen,Larry B. Vogler,Hans D. Ochs,Paolo Vezzoni,Wilhelm Friedrich,Klaus Schwarz +32 more
TL;DR: The clinical and immunologic phenotypes of patients bearing mutations in RAGs are more diverse than previously thought and that this variability is related, in part, to the specific type of RAG mutation.
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Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.
TL;DR: It is found that yeast and human TFIID yielded DAB complexes with different stabilities, and anti-TFIIB antibodies and reagents that affect the stability of a transcription-competent complex are found.
Journal ArticleDOI
The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor.
Shaobo Dou,Xiaoya Zeng,Patricia Cortes,H. Erdjument-Bromage,P. Tempst,Tasuku Honjo,L D Vales +6 more
TL;DR: Inhibition of transcription by RBP-2N was dependent on its DNA recognition site and was demonstrated in vitro and in vivo, and this repression appears to be general, as transcription mediated by SP1 and Gal4/VP16 was inhibited by RB p2N.
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RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.
TL;DR: By the use of the two-hybrid protein interaction system, a human protein that specifically interacts with RAG-1 is isolated, which is the human homologue of the yeast SRP1 (suppressor of a temperature-sensitive RNA polymerase I mutation).
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Andrographolide interferes with binding of nuclear factor-κB to DNA in HL-60-derived neutrophilic cells
María A. Hidalgo,Alex Romero,Jaime Figueroa,Patricia Cortes,Ilona I. Concha,Juan L. Hancke,Rafael A. Burgos +6 more
TL;DR: It is concluded that andrographolide exerts its anti‐inflammatory effects by inhibiting NF‐κB binding to DNA, and thus reducing the expression of proinflammatory proteins, such as COX‐2.