Z
Zhenglong Wang
Researcher at Zunyi Medical College
Publications - 12
Citations - 337
Zhenglong Wang is an academic researcher from Zunyi Medical College. The author has contributed to research in topics: Protein kinase B & PI3K/AKT/mTOR pathway. The author has an hindex of 5, co-authored 11 publications receiving 170 citations.
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Journal ArticleDOI
Exosomal circHIPK3 Released from Hypoxia-Pretreated Cardiomyocytes Regulates Oxidative Damage in Cardiac Microvascular Endothelial Cells via the miR-29a/IGF-1 Pathway.
Yan Wang,Ranzun Zhao,Weiwei Liu,Zhenglong Wang,Jidong Rong,Xianping Long,Zhijiang Liu,Junbo Ge,Bei Shi +8 more
TL;DR: CircHIPK3 in HPC-exos plays a role in CMVECs under oxidative conditions through miR-29a-mediated IGF-1 expression, leading to a decrease in oxidative stress-induced CMV ECs dysfunction.
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Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis.
TL;DR: Exosomal miR-21 derived from H2O2-treated MSCs could be transported to C-kit+ cardiac stem cells to functionally inhibit PTEN expression, thereby activating PI3K/AKT signaling and leading to protection against oxidative stress-triggered cell death.
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CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction.
Yan Wang,Chaofu Li,Ranzun Zhao,Zhimei Qiu,Changyin Shen,Zhenglong Wang,Weiwei Liu,Wei Zhang,Junbo Ge,Bei Shi +9 more
TL;DR: In this paper, the role of circular RNAs (circRNAs) in M2 macrophage (M2M)-derived small extracellular vesicles (SEVs) in myocardial fibrosis development was explored.
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Exosomal CircHIPK3 Released from Hypoxia-Induced Cardiomyocytes Regulates Cardiac Angiogenesis after Myocardial Infarction.
Yan Wang,Ranzun Zhao,Changyin Shen,Weiwei Liu,Jinson Yuan,Chaofu Li,Wenwen Deng,Zhenglong Wang,Wei Zhang,Junbo Ge,Bei Shi +10 more
TL;DR: This study provides a novel mechanism by which exosomal circRNAs are involved in the communication between CMs and cardiac endothelial cells and reports that hypoxic exosomes (HPC-exos) can effectively reduce theinfarct area and promote angiogenesis in the border surrounding the infarcted area.
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miR-21 Reduces Hydrogen Peroxide-Induced Apoptosis in c-kit+ Cardiac Stem Cells In Vitro through PTEN/PI3K/Akt Signaling.
TL;DR: Results indicate that the anti-H2O2-induced apoptosis effect of miR-21 in c-kit+ CSC is contributed by PTEN/PI3K/Akt signaling.