Z
Zhengyan Yang
Researcher at Henan University
Publications - 20
Citations - 399
Zhengyan Yang is an academic researcher from Henan University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 8, co-authored 12 publications receiving 292 citations.
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Journal ArticleDOI
Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop
Zhengyan Yang,Liang Guo,Dan Liu,Limin Sun,Hongyu Chen,Que Deng,Yanjun Liu,Ming Yu,Yuanfang Ma,Ning Guo,Ming Shi +10 more
TL;DR: It is implicate that the IL-6/STAT3/Jagged-1/Notch axis may be a useful target and that combination of the Notch or STAT3 inhibitors with trastuzumab may prevent or delay clinical resistance and improve the efficacy of trastzumab in gastric cancer.
Journal ArticleDOI
Glucocorticoid regulation of a novel HPV–E6–p53–miR‐145 pathway modulates invasion and therapy resistance of cervical cancer cells
Ming Shi,Libin Du,Dan Liu,Lu Qian,Meiru Hu,Ming Yu,Zhengyan Yang,Mingzhen Zhao,Changguo Chen,Liang Guo,Lina Wang,Lun Song,Yuanfang Ma,Ning Guo +13 more
TL;DR: The findings identify a novel pathway through which the neuroendocrine macroenvironment affects cervical tumour growth, invasion and therapy resistance and show that miR‐145 may serve as a target for cervical cancer therapy.
Journal ArticleDOI
Catecholamine-Induced β2-Adrenergic Receptor Activation Mediates Desensitization of Gastric Cancer Cells to Trastuzumab by Upregulating MUC4 Expression
Ming Shi,Zhengyan Yang,Meiru Hu,Dan Liu,Yabin Hu,Lu Qian,Wei Zhang,Hongyu Chen,Liang Guo,Ming Yu,Lun Song,Yuanfang Ma,Ning Guo +12 more
TL;DR: In vitro data indicated a novel trastuzumab resistance mechanism, by which catecholamine-induced β2-AR activation mediates desensitization of gastric cancer cells to trastzumab through upregulating the MUC4 expression.
Journal ArticleDOI
Adrenergic signaling promotes angiogenesis through endothelial cell–tumor cell crosstalk
Hongyu Chen,Dan Liu,Zhengyan Yang,Limin Sun,Que Deng,Shuo Yang,Lu Qian,Liang Guo,Ming Yu,Meiru Hu,Ming Shi,Ning Guo +11 more
TL;DR: Data demonstrate that tumor angiogenesis mediated by the Jagged 1/Notch intercellular signaling is governed by the norepinephrine-activated β2-AR-PKA-mTOR pathway.
Journal ArticleDOI
β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes
Ming Shi,Mingzhen Zhao,Meiru Hu,Dan Liu,Hong Cao,Lu Qian,Zhengyan Yang,Yabin Hu,Ming Yu,Shuo Yang,Yuanfang Ma,Ning Guo +11 more
TL;DR: Erbin mediates catecholamine-induced β2-AR/Her2 complexation and promotes catecholine-induced activation of ERK signaling in cardiomyocytes, conferring protection of cardiomeocytes from apoptosis induced by chronic catecholinamine stimulation.