Z
Zhi-yuan Pan
Researcher at Academy of Military Medical Sciences
Publications - 9
Citations - 85
Zhi-yuan Pan is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Endothelial stem cell & ATP-sensitive potassium channel. The author has an hindex of 6, co-authored 9 publications receiving 81 citations.
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Journal ArticleDOI
Targeting hypertension with a new adenosine triphosphate-sensitive potassium channel opener iptakalim.
TL;DR: Iptakalim has exerted protective effects against hypertensive damage to target organs in rats and improves endothelial dysfunction associated with cardiovascular diseases by selective activation of the SUR2B/Kir6.1 subtype of KATP channels expressed in the endothelium.
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The molecular pathway of ATP-sensitive potassium channel in endothelial cells for mediating arteriole relaxation
Xuejun Chen,Wen-Zhi Han,Yan-Fang Zhang,Wenyu Cui,Zhi-yuan Pan,Xin Jin,Chao-liang Long,Hai Wang,Hai Wang +8 more
TL;DR: It is suggested that Activation of endothelial TRPV1 channels and subsequent Ca(2+) entry, and NO release at least partly contribute to endothelium-dependent vasorelaxation induced by natakalim through increasing [Ca(2+)]i and NO production.
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The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function.
Yu Wang,Fu-hu Zeng,Chao-liang Long,Zhi-yuan Pan,Wen-Yu Cui,Ru-huan Wang,Guo-shu Liu,Hai Wang,Hai Wang +8 more
TL;DR: These results demonstrate that iptakalim could protect against IR-induced endothelial dysfunction, and ameliorate IR associated with hypertension, possibly via restoring the balance between NO and ET-1 signaling.
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Proteomics reveals potential non-neuronal cholinergic receptor-effectors in endothelial cells.
Yuan-yuan Zhang,Wei Shen,Lian-cheng Zhang,Zhi-yuan Pan,Chao-liang Long,Wenyu Cui,Yan-Fang Zhang,Hai Wang,Hai Wang +8 more
TL;DR: A set of proteins differentially expressed in endothelial cells in response to cholinergic agonists may have important implications for the downstream biological effects of NNAS.
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Stimulation of non-neuronal muscarinic receptors enhances chemerin/ChemR23 system in dysfunctional endothelial cells.
TL;DR: The modulation of arecoline on chemerin/ChemR23 signaling axis was absolutely abolished in the presence of the nonselective muscarinic receptors antagonist atropine 1 μmol/L and NNMR improves endothelial dysfunction.