Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: synthetic approaches and multifarious applications.

Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue

Quinazoline Synthesis via Rh(III)-Catalyzed Intermolecular C–H Functionalization of Benzimidates with Dioxazolones

Asymmetric Synthesis of Quaternary α‐Amino Acids and Their Phosphonate Analogues

Design, synthesis, and antibacterial activity of novel Schiff base derivatives of quinazolin-4(3H)-one.

Twenty-seven novel (E)-3-[2-arylideneaminoethyl]-2-[4-(trifluoromethoxy)anilino]-4(3H)-quinazolinone derivatives were synthesized by reacting various aromatic aldehydes with intermediate 6. The target compounds were characterized by 1H NMR, 3C NMR, IR, and elemental analysis. Bioassay results revealed that some of the compounds have strong antifungal activities against six fungi (Gibberella zeae, Fusarium oxysporum, Clematis mandshurica, Paralepetopsis sasakii, Phytophthora infestans, and Sclerotinia sclerotiorum) and three bacteria (Xanthomonas oryzae, tomato bacterial wilt, and tobacco bacterial wilt). Notably, these compounds exhibited the highest activity against tomato bacterial wilt and X. oryzae, with 50% effective concentration (EC50) values ranging from 45.96 to 93.31 μg/mL and from 20.09 to 21.33 μg/mL, respectively, which are superior to those of the commercial antibacterial agents thiodiazole-copper (99.80 μg/mL) and bismerthiazol (92.61 μg/mL). These results indicate that novel arylimine deri...

Synthesis and bioactivity evaluation of novel arylimines containing a 3-aminoethyl-2-[(p-trifluoromethoxy)anilino]-4(3H)-quinazolinone moiety.

Synthesis, antiviral activity, and 3D-QSAR study of novel chalcone derivatives containing malonate and pyridine moieties

The invention provides a novel empoasca vitis gothe attractant formula and application of the novel empoasca vitis gothe attractant The application method comprises the following steps: mainly preparing the attractant by the following components including tea tree volatile matters trans-2-hexenal, cis-3-hexene-1-ol and cis-3-hexenyl acetate, geraniol, linalool and trans-ocimene as components of the attractant and an additional antioxidant 2, 6-butylated hydroxytoluene (BHT) in a weight ratio of (05-50):(10-20):(10-15):(50-15):(30-40):(10-15):(10-10); loading the attractant on a silicone rubber head to prepare a lure; and embedding the lure on a yellow sticky colored card to form a trap of empoasca vitis gothe Imago of empoasca vitis gothe is trapped in a stable stage of trapping, preventing and treating the empoasca vitis gothe, so that the quantity of the empoasca vitis gothe can be effectively restricted Researches show that the lure with the novel empoasca vitis gothe attractant can obviously enhance the trapping and killing effects of a single yellow sticky colored card, the lasting trapping capacity of the trap to the empoasca vitis gothe can be remarkably improved, the service period of the trap is remarkably prolonged, and use of chemical pesticides in the tea garden is remarkably reduced and cancelled The attractant applied to the tea garden has the advantages of convenience in use, safety, greenness and no pollution and meets the national green prevention and control principle, thereby accelerating the industrial development of organic tea gardens

Empoasca vitis gothe attractant and application method thereof

A series of α-aminophosphonates containing a benzothiophene moiety was designed and synthesized All synthesized compounds were confirmed by 1H NMR, 13C NMR, 31P NMR, infrared spectroscopy, and elemental analysis The half-leaf method was used to determine the in vivo efficacy of α-aminophosphonates bearing a benzothiophene moiety against the tobacco mosaic virus (TMV) Bioassay results showed that all compounds exhibited certain anti-TMV activity at 500 μg/mL concentration Compound 2f exhibited a curative effect of up to 481% against TMV, which was almost similar to that obtained from the standard ningnanmycin (519%) [Supplementary materials are available for this article Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text, figures, and tables]

Design, Synthesis, and Antiviral Activity of α-Aminophosphonates Bearing a Benzothiophene Moiety

The invention discloses a compound capable of preventing and controlling plant virus disease, namely a pyridine-heterocycle-containing alpha-chalcone malonate derivative, as well as a preparation method and biological activity thereof. The pyridine-heterocycle-containing alpha-chalcone malonate derivative can be shown in a general formula (I) (described in the specification). According to the preparation method of the pyridine-heterocycle-containing alpha-chalcone malonate derivative, substituted phenylethanone, p-hydroxy benzaldehyde, absolute ethyl alcohol, sodium hydroxide, hydrochloric acid, 2-chloro-5-chloromethyl pyridine, acetone, potassium carbonate, potassium hydroxide and diethyl (dimethyl) malonate are taken as raw materials, and a target compound is synthesized by carrying out three-step reaction. The compounds a, d, o, e and w have good inhibiting effect on cucumber mosaic viruses and tobacco mosaic viruses. The general formula (I) is described in the specification.

Zhiwei Chen

Papers

Synthesis and bioactivity evaluation of novel arylimines containing a 3-aminoethyl-2-[(p-trifluoromethoxy)anilino]-4(3H)-quinazolinone moiety.

Synthesis, antiviral activity, and 3D-QSAR study of novel chalcone derivatives containing malonate and pyridine moieties

Empoasca vitis gothe attractant and application method thereof

Design, Synthesis, and Antiviral Activity of α-Aminophosphonates Bearing a Benzothiophene Moiety

Pyridine-heterocycle-containing alpha-chalcone malonate derivative as well as preparation method and application thereof