Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

Therapeutically active compounds and their methods of use

The present invention provides a compound which is useful as an inhibitor against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. As a result of extensive and intensive studies on compounds having an inhibitory effect against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins, the inventors of the present invention have found that the di(arylamino)aryl compound of the present invention has inhibitory activity against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. This finding led to the completion of the present invention. The compound of the present invention can be used as a pharmaceutical composition for preventing and/or treating cancer, lung cancer, non-small cell lung cancer, small cell lung cancer, EML4-ALK fusion polynucleotide-positive and/or mutant EGFR polynucleotide-positive cancer, EML4-ALK fusion polynucleotide-positive and/or mutant EGFR polynucleotide-positive lung cancer, or EML4-ALK fusion polynucleotide-positive and/or mutant EGFR polynucleotide-positive non-small cell lung cancer, etc.

Di(arylamino)aryl compound

The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are c...

https://www.tandfonline.com/doi/pdf/10.1080/13543776.2021.1857726

Protease inhibitors targeting the main protease and papain-like protease of coronaviruses.

A method for detecting starch sample fibering of starch sample protein in a biological sample is provided. The method comprises enabling a water-soluble aggregated induced luminescence (AIE) illuminant to contact with the biological sample and detecting the fluorescent light, wherein the water-soluble AIE illuminant comprises a formula I skeleton structure, A is selected from-CN or R, R(1)is independently selected from H, XSO3-R, XN(CH3)3+Br-,XN(CH2CH3)3+Br-or XCOOR, X is selected from O(CH2),n is an integral number from 1 to 20, R(2) is selected from alkali metal or alkaline earth metal ion, when A is-CN,R is not H, and when A is, at least one of R and R(1) is not H.

Water-soluble aie illuminant and purpose of the illuminant in detecting and delaying starch sample fibering of starch sample protein

Provided are compounds of formula (I), wherein: ring A and ring B are each independently an optionally substituted 5-6 membered monocyclic aryl or heteroaryl; one of X, Y and W is CH and the two others are N; and Z is H or -C(R1)(R2)(R3). The compounds are inhibitors of isocitrate dehydronenase 2 (IDH2) mutants useful for treating cancer.

2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer

This invention discloses the substituted [1,3,5] triazine compounds of following formula, their pharmaceutically acceptable salts and solvates or hydrates, the pharmaceutical compositions containing the compounds and the uses thereof. The compositions of the present invention may be used for the prevention and/or treatment of inflammation diseases, which have good effect. The substituted [1,3,5] triazine compounds or their pharmaceutically acceptable salts show remarkable EGFR enzyme inhibitory activity and antitumor activity in a serious of selective tests of EGFR enzyme level and tumor cell level (human HT-29 and HCT-116). So The compositions of the present invention may be used for the prevention and/or treatment and/or aid treatment of tumor diseases.

Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof

A compound for inhibiting beta-starch protein aggregation and fibrillation or its medicinal accepted slat, composition, its production and use in prevention and treatment of Alzheimer's disease are disclosed. The compound or medicinal accepted slat combines with Alpha-beta polypeptide and inhibits Alpha-beta polypeptide aggregation and fibrillation.

Small molecule inhibitor for preventing Alzheimer's disease Abeta polypeptide from fiberizing and its preparation method, pharmaceutical composition and application

The invention relates to field of medical design, medical chemistry and pharmaceutics. The invention intends to find out molecule that can activate or prevent potassium ion channel activity by employing computer on the basis of crystal three-dimensional structure of potassium ion channel, then derivatives sifted compound and provides N, N'- disubstituted piperazine derivatives and its salt accepted by pharmacy. The construction formula of said derivatives is expressed in following graph. The invention also relates to the method for preparing said derivatives and its salt and their application. Said compound can be used as activating agent or preventing agent for potassium ion channel, and the potassium ion can be selectively shifted in or out cell by activating or preventing the activity of potassium ion channel. The compound mentioned in this invention can be used to treat and/ or prevent cranial vascular disease relevant to physiological pathological and pharmacologia of cardiovascular system effectively.

N,N'-disubstituted piperazine derivative, and its preparation method and medicinal composition and uses

The present invention relates to the fields of medicinal chemistry and pharmacotherapy, and specifically relates to a compound represented by general formula (I). The compound is used as an enterovirus protease inhibitor, and also exerts a significant inhibitory activity on a main protease of a coronavirus (such as SARS), and can be used to treat related diseases. This invention also relates to a preparation method, pharmaceutical composition, pharmaceutical salt, enantiomorph, diastereomer, and racemic mixture of the compound.

Aldehyde and preparation and application thereof

The invention relates to an indoles compound, a preparation method, a pharmaceutical composition and an application thereof. The indoles compound has a structure shown in a general formula(I), can be used for treating disease related to alpha1-adrenocepter, and especially for treating urinary system diseases such as prostatoplasia, urinary retention and bladder outlet obstruction.

Zhou Yu

Papers

Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof

Small molecule inhibitor for preventing Alzheimer's disease Abeta polypeptide from fiberizing and its preparation method, pharmaceutical composition and application

N,N'-disubstituted piperazine derivative, and its preparation method and medicinal composition and uses

Aldehyde and preparation and application thereof

Indoles compound, preparation method thereof, pharmaceutical composition and application thereof