Mariya A. Smetanina, Andrey I. Shevela, Konstantin A. Gavrilov, Maxim L. Filipenko Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM) SB RAS, Novosibirsk 630090, Russia. Department of Fundamental Medicine, V. Zelman Institute for Medicine and Psycology (NSU), Novosibirsk 630090, Russia. Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM) SB RAS, Novosibirsk 630090, Russia. Department of Surgical Diseases, V. Zelman Institute for Medicine and Psycology (NSU), Novosibirsk 630090, Russia. Department of Clinical Biochemistry, V. Zelman Institute for Medicine and Psycology (NSU), Novosibirsk 630090, Russia.

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The genetic constituent of varicose vein pathogenesis as a key for future treatment option development

Objective To investigate the association of polymorphisms located near the FOXC2 gene with the risk of varicose veins in ethnic Russians. Methods Allele, genotype, and haplotype frequencies were determined in the sample of 474 patients with primary varicose veins and in the control group of 478 individuals without a history of chronic venous disease. Results Polymorphisms rs7189489, rs4633732, and rs1035550 showed the association with the increased risk of varicose veins, but none of the observed associations remained significant after correction for multiple testing. Haplotype analysis revealed the association of haplotype rs7189489 C–rs4633732 T–rs34221221 C–rs1035550 C–rs34152738 T–rs12711457 G with the increased risk of varicose veins (OR = 2.67, P = 0.01). Conclusions Our results provide evidence that the studied polymorphisms do not play a major role in susceptibility to varicose veins development in the Russian population.

Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians

Эпигенетика популяций, экотоксикогенетика и болезни человека

Дифференциальная экспрессия генов и активация сигнальных путей в радиорезистентных и радиочувствительных раковых клеточных линиях

October 19, 2022 marked the 75th anniversary of the birth of Academician of the Russian Academy of Sciences, Professor, Doctor of Medical Sciences Alexander Ivanovich Kiriyenko a recognized leader in the field of phlebology.

To the 75th Anniversary of Academician of the Russian Academy of Sciences Alexander Ivanovich Kiriyenko

Varicose veins of the lower limbs are one of the most common and wide-spread pathology all around the world. What triggers the specific changes in a vein wall still remains unclear as well as what happens in the layers of the vein wall after the disease starts. The aim of the article is to analyze published data and results of researches on epidemiology, genetics, cellular and molecular mechanisms underlying varicose veins pathogenesis. It is now commonly accepted that vein wall changes in patients with varicose veins result from vein-specific inflammation. This process includes leukocytes adhesion to venous endothelium with their subsequent migration into the vein wall and surrounding tissues. Activated leukocytes express a number of molecules that lead to vein wall remodeling and dilation. Comprehensive assessment of the epidemiological data on the prevalence of varicose veins and risk factors, of the findings from genetic studies, of data on molecular-cell interactions as well as results of various surgical interventions in patients with varicose veins, shows that remodeling is a reversible process that can be stopped and reversed by different stimuli including some chemical substances. For the first time in the literature, the authors assume that varicose veins can be successfully cured pharmacologically with no surgical interventions needed.

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Золотухин Игорь Анатольевич

Papers

Varicose veins: on the verge of discovering the cause?