Varicose veins: on the verge of discovering the cause?
Igor A. Zolotukhin,Золотухин Игорь Анатольевич,Olga Ya. Porembskaya,Порембская Ольга Ярославна,Mariya A. Smetanina,Сметанина Мария Александровна,Aleksandr V. Sazhin,Сажин Александр Вячеславович,Maksim L. Filipenko,Филипенко Максим Леонидович,A. I. Kirienko,Кириенко Александр Иванович +11 more
- Vol. 75, Iss: 1, pp 36-45
TLDR
Comprehensive assessment of the epidemiological data on the prevalence of varicose veins and risk factors, of the findings from genetic studies, of data on molecular-cell interactions as well as results of various surgical interventions in patients with varicOSE veins, shows that remodeling is a reversible process that can be stopped and reversed by different stimuli including some chemical substances.Abstract:
Varicose veins of the lower limbs are one of the most common and wide-spread pathology all around the world. What triggers the specific changes in a vein wall still remains unclear as well as what happens in the layers of the vein wall after the disease starts. The aim of the article is to analyze published data and results of researches on epidemiology, genetics, cellular and molecular mechanisms underlying varicose veins pathogenesis. It is now commonly accepted that vein wall changes in patients with varicose veins result from vein-specific inflammation. This process includes leukocytes adhesion to venous endothelium with their subsequent migration into the vein wall and surrounding tissues. Activated leukocytes express a number of molecules that lead to vein wall remodeling and dilation. Comprehensive assessment of the epidemiological data on the prevalence of varicose veins and risk factors, of the findings from genetic studies, of data on molecular-cell interactions as well as results of various surgical interventions in patients with varicose veins, shows that remodeling is a reversible process that can be stopped and reversed by different stimuli including some chemical substances. For the first time in the literature, the authors assume that varicose veins can be successfully cured pharmacologically with no surgical interventions needed.read more
Citations
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The genetic constituent of varicose vein pathogenesis as a key for future treatment option development
TL;DR: This work presents a meta-anatomy of the immune system of Novosibirsk, a model for the treatment of central giant cell granuloma, which is the most common cause of cancer in women.
Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians
TL;DR: Analysis of polymorphisms located near the FOXC2 gene in ethnic Russians provides evidence that the studied polymorphisms do not play a major role in susceptibility to varicose veins development in the Russian population.
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To the 75th Anniversary of Academician of the Russian Academy of Sciences Alexander Ivanovich Kiriyenko
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