Zong Yi Li

TL;DR: A novel pathway that is used by Ad for infection of hepatocytes and Kupffer cells upon intravenous virus application in mice is described and it is found that blood factors play a major role in targeting Ad vectors to hepatic cells.

TL;DR: DSG-2 is identified as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14, which represent key human pathogens causing respiratory and urinary tract infections and may have implications for cancer therapy.

TL;DR: The studies indicated that Kupffer cells were not the major reservoir for the observed accumulation of Ads, and the lower level of liver cell transduction by short-shafted Ads correlated with a significantly reduced inflammatory anti-Ad response as well as liver damage induced by the systemic administration of these vectors.

TL;DR: A new pathway involved in unspecific Ad5 sequestration and degradation is discovered and construction of vectors that avoid it could improve levels of target cell transduction at lower vector doses.

TL;DR: A Ad5-based chimeric vector containing sequences encoding the Ad35 fiber knob domain instead of the Ad5 knob (Ad5/35L) is utilized to analyze factors responsible for selection of intracellular trafficking routes by Ads and contributes to a better understanding of the mechanisms that govern the infection of retargeted, capsid-modified vectors.