Zsofia Lengyel-Zhand

TL;DR: The intact Sigma-2 receptor complex may potentially be a novel pharmacological target to decrease neuronal Aβ42 internalization and accumulation, which may represent a new strategy for inhibiting the rate of neurotoxicity, neurodegeneration, and progression of AD.

TL;DR: Ultra-high throughput in silico screening identified molecules that bind to α-synuclein fibrils, which were analyzed by photo-crosslinking, structure-activity studies, and radioligand binding to validate this approach for finding imaging probes.

TL;DR: The intact Sigma-2 receptor complex may potentially be a novel pharmacological target to decrease neuronal Aβ42 internalization and accumulation, which may represent a new strategy for inhibiting the rate of neurotoxicity, neurodegeneration, and progression of AD.

TL;DR: This work explores benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes that have high affinity for α- synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue.

TL;DR: In this article, the PAR-pαSyn interactions were investigated using immunofluorescence-based assays to explore if PAR-1 enzymatic product (PAR) promotes the aberrant cytoplasmic accumulation of pαSyn.