Z
Zsuzsanna Rozmer
Researcher at University of Pécs
Publications - 19
Citations - 453
Zsuzsanna Rozmer is an academic researcher from University of Pécs. The author has contributed to research in topics: Chalcone & Chemistry. The author has an hindex of 8, co-authored 16 publications receiving 355 citations.
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Journal ArticleDOI
Naturally occurring chalcones and their biological activities
Zsuzsanna Rozmer,Pál Perjési +1 more
TL;DR: The aim of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants to initiate further pharmacobotanical, biotechnological and medicinal studies on the field of chal cone research.
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Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells
Pál Perjési,Umashankar Das,Erik De Clercq,Jan Balzarini,Masame Kawase,Hiroshi Sakagami,James P. Stables,Tamás Lóránd,Zsuzsanna Rozmer,Jonathan R. Dimmock +9 more
TL;DR: A series of 3-benzylidene-4-chromanones 1a-l were prepared and their cytotoxicity towards human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 lymphoid leukemia cells were compared to the previously generated biodata in these three assays for the isosteric 2-benza-1-tetralones 2a- l.
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Different effects of two cyclic chalcone analogues on cell cycle of Jurkat T cells
TL;DR: Investigation of antioxidant capacity of the compounds by monitoring time course of the Fenton-reaction initiated in vitro degradation of 2-deoxyribose indicated that both compounds displayed hydroxyl radical scavenger activity.
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Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria
Juraj Guzy,J. Vašková-Kubálková,Zsuzsanna Rozmer,Krisztina Fodor,Mária Mareková,Martina Poškrobová,Pál Perjési +6 more
TL;DR: Increased radical generation and possible covalent interaction of the compounds with cellular thiols resulted in glutathione (GSH) depletion and modulation of the investigated mitochondrial activities.
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Different effects of two cyclic chalcone analogues on redox status of Jurkat T cells
TL;DR: The investigations provide further details of dual - cytotoxic and chemopreventive - effects of the cyclic chalcone analogues.