Showing papers by "Binzhou Medical College published in 2001"

Enteral nutrition and acute pancreatitis.

Abstract: Acute pancreatitis (AP) is a common severe illness of the digestive tract with variable involvement of other regional tissues and/or remote organ systems[1-3]. Mild disease is associated with minimal organ dysfunction and rapid recovery, while severe disease is associated with multiple organ system failure and local complications such as necrosis, abscess, fistulas and pseudocyst formation [4-6]. Mild attacks account for 80% of hospital admissions for this condition and usually resolve in 5 to 7 days. Twenty percent of patients with severe acute pancreatitis (SAP) tend to have a more protracted hospital course with higher mortality, and are more likely to require a multidisciplinary treatment that includes Nutritional support[7-9]. Nutritional support in the patients with AP is both very critical and more complex. In the past years, parenteral Nutrition (PN) was recommended for patients with AP[10,11], but recently, significant progress has been achieved in the field of enteral Nutrition (EN)[12,13]. Clinical research has shown that early delivery of Nutrition via the gastrointestinal tract after severe injury can reduce septic morbidity in critically injured patients [14-18]. Enteral diets have been reported to decrease Gut permeability and maintain mucosal immunity and Gut-associated lymphatic tissue (GALT)[19-21]. These observations provide new insights into the use of EN. Therefore, more and more clinicians have begun to use this technique for patients with AP. This review examines metabolic alterations of AP and effects on pancreatic secreration of EN, evaluates the indications, feeding access and formulas of EN, and assesses the clinical role of EN in AP.

Influence of IFN alpha-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma.

Abstract: Influence of IFNα-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma

Photosensitization of hypomycin B--a novel perylenequinonoid pigment with only one intramolecular hydrogen bond.

Abstract: Electron spin resonance technique and spin-trapping methods were used to determine the photoproduction of 1O2 and O2.- by hypomycin B (HMB), a novel perylenequinonoid pigment (PQP) possessing only one hydroxyl group. It was found that the yields of 1O2 and O2.- for HMB were comparable to those for hypocrellin A, a typical natural PQP with good photosensitivity. In addition, the absorption and fluorescence spectra for HMB were investigated. The pKa values in the ground and excited states of HMB were determined to be 8.94 and 5.54, respectively. Thus, the photodynamic mechanisms of HMB may involve not only the photogeneration of 1O2 and O2.- but also the light-induced acidification. Consequently, HMB is proposed to be a good photodynamic therapeutic agent.

Structural elucidation of a new perylenequinone

Abstract: Aim To study the chemical constituents from the mycelia of Hypomyces sp. Methods Silica gel column chromatography was employed for the isolation and purification. The structure of compound 1 was elucidated on the basis of spectral analysis. Results and conclusion A new perylenequinone, named hypomycin B 1, was isolated from the mycelia of Hypomyces sp.