Showing papers by "Casa Sollievo della Sofferenza published in 1978"

MAO activity in rat brain stem and cerebral cortex: effect of acute and chronic treatment with ethanol and tetrahydropapaveroline

Abstract: Brain mitochondria were prepared from rat brain stem and cerebral cortex. Four substrates were used for enzyme characterization: dopamine, serotonin, noradrenaline and tryptamine. Monoamine oxidase (MAO) activities were tested on two different groups of rats treated with ethanol and tetrahydropapaveroline (THP); another group was used as control group. Data obtained show that there is almost always activation of MAO activities after acute treatment with either ethanol or THP, while after chronic treatment, the two drugs show opposite effects. In particular, the same type of MAO activity continues to be activated by ethanol, whereas it is inhibited by THP.

Lymphoid antigens on blast cells in the agranular metamorphosis of chronic myelogenous leukaemia.

Abstract: Undifferentiated blasts from a Ph’-positive chronic myelogenous leukaemia (CML) in terminal metamorphosis were reacted in an indirect immunofluo-rescence test with antilymphocytic globulins (AHLGs), raised against cultured lymphoblasts, thoracic duct and peripheral blood lymphocytes from healthy donors. After proper myeloid and/or monocytic absorptions the AHLGs interacted strongly with the undifferentiated blasts of CML, while this was not true for parallel controls with non-lymphoid leukaemias, both acute and chronic. The intensity of fluorescence, as determined by the use of a microfluorimeter, on these agranular blasts was comparable to the positivity of lymphoid cells from acute and chronic lymphatic leukaemias. These findings lend further support to the conception of a lymphoblast-like variety of terminal blastic crisis in chronic myelogenous leukaemia.