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Alessandro Bertolino
Researcher at University of Bari
Publications - 275
Citations - 21028
Alessandro Bertolino is an academic researcher from University of Bari. The author has contributed to research in topics: Prefrontal cortex & Schizophrenia. The author has an hindex of 62, co-authored 275 publications receiving 18385 citations. Previous affiliations of Alessandro Bertolino include National Institutes of Health & Hoffmann-La Roche.
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
Journal ArticleDOI
Physiological Dysfunction of the Dorsolateral Prefrontal Cortex in Schizophrenia Revisited
Joseph H. Callicott,Alessandro Bertolino,Venkata S. Mattay,Frederick J.P. Langheim,Jeff H. Duyn,Richard Coppola,Terry E. Goldberg,Daniel R. Weinberger +7 more
TL;DR: The data suggest that under certain conditions the physiological ramifications of dorsal PFC neuronal pathology in schizophrenia includes exaggerated and inefficient cortical activity, especially of lateral PFC.
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Physiological characteristics of capacity constraints in working memory as revealed by functional MRI.
Joseph H. Callicott,Venkata S. Mattay,Alessandro Bertolino,Kimberly Finn,Richard Coppola,Joseph A. Frank,Terry E. Goldberg,Daniel R. Weinberger +7 more
TL;DR: It is demonstrated that regionally specific nodes within the working memory network are capacity-constrained in the physiological domain, providing a missing link in current explorations of the capacity characteristics of working memory.
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Prefrontal neurons and the genetics of schizophrenia.
Daniel R. Weinberger,Michael F. Egan,Alessandro Bertolino,Joseph H. Callicott,Venkata S. Mattay,Barbara K. Lipska,Karen F. Berman,Terry E. Goldberg +7 more
TL;DR: Family-based association studies and functional magnetic resonance imaging provide convergent evidence that the COMT val allele increases risk for schizophrenia by virtue of its effect on dopamine-mediated prefrontal information processing-the first plausible mechanism for a genetic effect on normal human cognition and risk for mental illness.
Journal ArticleDOI
Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia.
Joseph H. Callicott,Michael F. Egan,Venkata S. Mattay,Alessandro Bertolino,Ashley D. Bone,Beth Verchinksi,Daniel R. Weinberger +6 more
TL;DR: In this article, the authors used functional magnetic resonance imaging (fMRI) during performance of the N-back working memory task to assess working memoryrelated cortical physiology in nonschizophrenic, cognitively intact siblings of patients with schizophrenia.