Showing papers by "Dr. Hari Singh Gour University published in 1995"
TL;DR: In vivo distribution studies of the prepared niosomes found that 65% of the drug could be localized in the lungs by controlling the niosome size.
Abstract: Niosomes (non-ionic, surfactant-based vesicles) containing rifampicin of 8-15 microns in diameter were prepared using Span-85 and cholesterol in various molar fractions. The process variables that could affect the physical characteristics of niosomes and in vitro release of the drug from the niosomes were studied and optimized. In vivo distribution studies of the prepared niosomes found that 65% of the drug could be localized in the lungs by controlling the niosome size.
100 citations
TL;DR: The application of liposomal diclofenac resulted in localization of the drug at the site of application with slow systemic availability; however, with the application of ultrasound pulsed drug systemic levels could be achieved.
Abstract: Liposomes containing diclofenac, an anti-inflammatory agent were incorporated into an ointment base for topical application. The drug loaded liposomes were characterized for various physico-chemical attributes and drug efflux profile in in vitro. The systemic availability of drug from liposomes following topical application was evaluated in rats. The effect of sonophoresis on the drug release profile in oitro and systemic availability in vivo was established. The application of liposomal diclofenac resulted in localization of the drug at the site of application with slow systemic availability; however, with the application of ultrasound pulsed drug systemic levels could be achieved.
39 citations
TL;DR: In vivo experiments revealed that the nasal administration of liposomes eliminated hepatic first-pass metabolism and could maintain an effective drug concentration for prolonged periods of time with improved bioavailability.
34 citations
TL;DR: An enhanced anti-inflammatory activity of lipo-indomethacin was found as compared with the activity recorded for plain drug in carrageenan induced paw oedema in rats.
Abstract: Indomethacin, a non-steroidal anti-inflammatory drug was successfully entrapped into liposomes (soyabean lecithin, cholesterol, stearylamine or dicetylphosphate) with uniform size distribution. The liposomal vesicles were derived from dried effervescent granule-based proliposomes. The in vivo distribution characteristics of the reconstituted liposomal indomethacin was studied in normal rats and in the rats with inflamed paws following intravenous administration. The localization of the liposome-based indomethacin was in liver, lungs and inflamed tissues (inflamed rats studies). Further, an enhanced anti-inflammatory activity of lipo-indomethacin was found as compared with the activity recorded for plain drug in carrageenan induced paw oedema in rats.
22 citations
TL;DR: It has been observed that the release rate of rifampicin, contained in the internal phase, increased significantly on addition of calcium stearate and/or soya lecithin to the organic phase.
Abstract: The formation of multiple w/o/w emulsions with improved stability by using interfacial complex films between polyvinyl alcohol, acacia, polyvinylpyrrolidone and sorbitan monooleate (Span 80) is described. The long term stability of the emulsions, as assessed by microscopy and particle size analysis, showed no changes in the w/o/w emulsion systems prepared using these macromolecules in the internal phase. It has also been observed that the release rate of rifampicin, contained in the internal phase, increased significantly on addition of calcium stearate and/or soya lecithin to the organic phase.
15 citations
TL;DR: The plasma level observed indicated that poloxamer coating results in prolonged release of the drug, and organ distribution demonstrated a different distribution pattern when compared with uncoated microcapsules.
Abstract: The three-ply-walled-based system for controlled delivery of diclofenac was developed. The preparation of three-ply-walled microcapsules is essentially based on the technique of multiple-emulsion formation polymer at the interface followed by rigidization of the wall on evaporation of solvent. The protective colloids with surface-active properties were selected for the present study, viz. acacia gelatin, polyvinyl alcohol and sodium alginate. Ethyl cellulose was taken as hydrophobic polymer. The acacia/ethylcellulose/acacia-based three-ply-walled microcapsule system was selected for further studies. The three-ply-walled microcapsule were subsequently coated with poloxamer 188. The non-ionic hydrophilic surfactant coating retards uptake into the reticuloendothelial system. The coated and uncoated microcapsules were characterized for in vitro and in vivo performance. The microcapsules were noted to provide sustained release of the contained diclofenac. The plasma level observed indicated that poloxa...
10 citations
TL;DR: In this paper, an accurate intramolecular force field for ethynylbenzene and its three deuterated isomers was determined from experimentally observed vibrational frequencies.
5 citations