Showing papers by "Dr. Hari Singh Gour University published in 2004"

Anti-Helicobacter pylori effect of mucoadhesive nanoparticles bearing amoxicillin in experimental gerbils model.

Abstract: The purpose of the present study was to design mucoadhesive gliadin nanoparticles (GNP) containing amoxicillin and to evaluate their effectiveness in eradicating Helicobacter pylori. GNP-bearing amoxicillin (AGNP) was prepared by desolvation method. The effect of process variables such as gliadin concentration and initial drug loading on particle size, shape, percent payload, percent entrapment efficiency, in vitro release profile, and mucoadhesive property of GNP was assessed. Rhodamine isothiocyanate-entrapped GNP formulations were prepared to evaluate their in vivo gastric mucoadhesive property in albino rats. With increasing gliadin concentration, the mucoadhesive property of GNP increased. Typically, the maximum amount of nanoparticles remaining was 82±4%, which represented a stronger mucoadhesive propensity and specificity of GNP toward the stomach. In vitro antimicrobial activity of AGNP was evaluated by growth inhibition studies on an isolated H pylori strain. The time required for complete eradication was higher in AGNP than in amoxicillin because of the controlled drug delivery of amoxicillin from AGNP. In vivo clearance of H pylori following oral administration of AGNP to infected Mongolian gerbils was examined. Amoxicillin and AGNP both showed anti-H pylori effects in this experimental model of infection, but the required dose for complete eradication was less in AGNP than in amoxicillin. In conclusion, AGNP eradicated H pylori from the gastrointestinal tract more effectively than amoxicillin because of the prolonged gastrointestinal residence time attributed to mucoadhesion. A dosage form containing mucoadhesive nanoparticles bearing a potential antibiotic should be useful for the complete eradication of H pylori.

Chemical and Structural Studies of Some Transition Metal Tellurite Complexes with 1,3‐Diaminopropane

Abstract: Complexes of some Co(II), Ni(II), and Cu(II) tellurites with 1,3‐diaminopropane ligand have been prepared and charaterized on the basis of elemental analyses, conductivity, magnetic moments, and spectral studies. These complexes have the general formula [ML n (H2O) x ]TeO3 · yH2O, where M(II) = Co(II), Ni(II), and Cu(II); L = 1,3‐diaminopropane; n = 3 [for Co(II)] and 2 [for Ni(II) and Cu(II)]; x = 0 [for Co(II) and Cu(II)] and 2 [for Ni(II)]; y = 4, 1 or 6 [for Co(II), Ni(II), and Cu(II) complexes, respectively]. TGA studies have also been carried out to study the patterns of their decomposition. The lattice constants and other cell parameters of the cobalt(II), nickel(II), and copper(II) tellurite complexes have been determined with the help of x‐ray powder diffraction data. The Co(II) and Ni(II) complexes have an orthorhombic unit cell, whereas the Cu(II) complex has a tetragonal unit cell. On the basis of the cell parameters and diffraction data it has been concluded that the Co(II), Ni(II), ...

Synthesis and Biological Activity of 4‐Oxothiazolidines and Their 5‐Arylidenes.

Abstract: A series of 5-arylidene-2-aryl-3-[(2-benzothiazolylthio)-acctamidyl]-1,3-thiazolidin-4-ones have been synthesised by appropriate methods. All the compounds have been screened for their antifungal activity against Candida albicans, Fusarium heterosporium and Aspergillus niger, antibacterial activity against Bacillus substilis, Salmonella typhimurium and Escherchia coli, and anti inflammatory activity against the carrageenan induced rat paw oedema in albino rats and anthelmintic activity against the experimental infection of Ancyclostoma ceylanicum and Hymenolepsis nana in rats. In the primary screening, some of the compounds exhibit appreciable activity. The structures of the synthesised compounds (4 and 5) have been established on the basis of their elemental analyses and spectral data.