Showing papers by "Eppley Institute for Research in Cancer and Allied Diseases published in 1981"
TL;DR: In the 4-MPH-treated females and some AMPH-treated male mice, a few soft-tissue tumors were observed; however, their appearance could not be related to treatment.
Abstract: 4-Methylphenylhydrazine hydrochloride (4-MPH) was administered to randomly bred Swiss mice as 26 weekly sc injections of 140 microgram per gram of body weight and N'-acetyl-4-(hydroxymethyl)phenylhydrazine (AMPH) as 26 weekly sc injections of 500 microgram/g As a solvent control, physiological saline was also given as 26 weekly sc injections of 001 ml/g The 4-MPH treatment induced a significant incidence (24%) of fibrosarcomas in males In the 4-MPH-treated females and some AMPH-treated male mice, a few soft-tissue tumors were observed; however, their appearance could not be related to treatment 4-MPH is formed under special experimental conditions from 4-hydroxymethylphenyl-hydrazine, which is an in vitro breakdown product of agaritine, an ingredient of the cultivated mushroom Agaricus bisporus The implications of the findings are discussed
57 citations
TL;DR: A solution of 0.0625% 1, 2-di-n-butylhydrazine dihydrochloride (1,2-DBH) was given continuously in the drinking water of 6-week-old randomly bred albino Swiss mice for the remainder of their lives and gave rise to tumors of the lungs, lymphoreticular tissue and kidneys.
Abstract: A solution of 0.0625% 1,2-di-n-butylhydrazine dihydrochloride (1,2-DBH) was given continuously in the drinking water of 6-week-old randomly bred albino Swiss mice for the remainder of their lives. The treatment gave rise to tumors of the lungs, lymphoreticular tissue and kidneys.
5 citations
TL;DR: Whether the dialkyl derivatives of hydrazine are more active carcinogens than the monoalkyl analogues is disclosed, as part of a structure activity inquiry.
Abstract: Lifetime administration of 0.03125% 1,1-di-n-butylhydrazine in drinking water to Swiss mice, from 6 weeks of age, induced tumors of the lungs, forestomach and liver. The tumor incidences in these tissues in untreated controls were 25, 2 and 0.5%, whereas in the treated groups the corresponding tumor incidences increased to 68, 39 and 5%, respectively. Histopathologically these lesions were classified as adenomas and adenocarcinomas of the lungs, squamous cell papillomas and carcinomas of the forestomach, and benign hepatomas and liver cell carcinomas. The work is part of a structure activity inquiry and its specific aim is to disclose whether the dialkyl derivatives of hydrazine are more active carcinogens than the monoalkyl analogues.
4 citations