Showing papers by "Eppley Institute for Research in Cancer and Allied Diseases published in 1982"
TL;DR: The vulnerability to EBV of males with XLP and why their mothers are protected from life‐threatening phenotypes of XLP are explained, in part, by the results of the regression assays correlated with their EBV serology.
Abstract: The activity of T-cell-mediated immunity to Epstein-Barr virus (EBV) was assessed by an assay of regression of the outgrowth of EBV-infected autologous B cells. Regression and natural killer (NK)-cell activities were compared for patients and their mothers from five families with X-linked lymphoproliferative syndrome (XLP) and three control groups. Seven of the 10 patients with XLP exhibited weak T-cell activity against autologous EBV-infected lymphoblastoid cell lines (LCL) comparable to EBV-seronegative controls. In contrast, 8 of 10 obligate carrier females of XLP had unusually strong activity, which was comparable to anti-early-antigen (EA) positive controls. The results of the regression assays correlated with their EBV serology: mothers showed high titers, and their affected sons showed low-titer EBV-specific antibody responses. Defective NK-cell activity was found only in the patients with XLP. NK and regression activities did not correlate. Our findings explain, in part, the vulnerability to EBV of males with XLP and why their mothers are protected from life-threatening phenotypes of XLP.
61 citations
TL;DR: Syrian hamsters were fed one of three levels of lactalbumin (10, 20 or 40%) or a commercial diet from 4 weeks of age and parents and offspring remained for life on the assigned parental diet and reproduced better in hamsters fed the commerical diet than in those given purified diets.
Abstract: Syrian hamsters were fed one of three levels of lactalbumin (10, 20 or 40%) or a commercial diet from 4 weeks of age. The hamsters were mated at 12 weeks of age and parents (F0 generation) and offspring (Fi generation) remained for life on the assigned parental diet. Hamsters were killed to evaluate nutritional status from both generations at 4, 10, 22, 34 and 64 weeks of age. Remaining hamsters were allowed to live out their natural lifespan. Female hamsters generally grew faster with each incre ment in lactalbumin. Growth was greatest in male hamsters on the 20% lactalbumin diet and greater in the FI than in the F0 generation. Reproduction was superior in hamsters fed the commercial diet and differed by season in those given purified diets, with the best performance following the autumn matings. Litter size and body weights of offspring at weaning increased from hamsters fed 10%of those fed higher levels. In the FOgeneration, the longest female lifespans were observed in the 20 and 40% lact albumin groups, with shorter survivals in the 10% and commercially fed groups, re spectively. The F! generation females had longer survivals with each increase in lact albumin. Male survival in both generations increased from the commercial diet to the 40 and 10% lactalbumin levels and was greatest in males fed 20% lactalbumin diet. J. Nutr. 112: 2151-2160, 1982.
17 citations
TL;DR: N-methyl-N-formylhydrazine is a stable constituent of the edible false morel mushroom Gyromitra esculenta and the environmental significance is discussed, in view of the carcinogenicity of minute doses of this chemical.
Abstract: Separate administrations of 0.0005 to 0.00025% N-methyl-N-formylhydrazine in drinking water to 6-week-old randomly bred Swiss mice for the remainder of their lifetime induced lung neoplasms. At the high dose level, 64% of the females and 48% of the males developed lung tumors, while the corresponding tumor incidences at the lower dose level were 62% in the females and 54% in the males. In untreated controls, the lung tumor incidences were 29% in the females and 19% in the males. Histopathologically, the lesions were classified as adenomas and adenocarcinomas of the lungs. N-methyl-N-formylhydrazine is a stable constituent of the edible false morel mushroom Gyromitra esculenta. The environmental significance is discussed, in view of the carcinogenicity of minute doses of this chemical.
7 citations
TL;DR: The data indicate that even though PCN and DEX slightly increase aryl hydrocarbon hydroxylase (AHH) activity and metabolism of B[a]P, they have opposite effects on cellular transformation.
1 citations
TL;DR: It is concluded that these compounds are apparently noncarcinogenic under the present experimental conditions and have no detectable tumorigenic effects in the treated animals.