Federal University Otuoke

About: Federal University Otuoke is a education organization based out in Ogbia, Nigeria. It is known for research contribution in the topics: Adsorption & Corrosion inhibitor. The organization has 145 authors who have published 279 publications receiving 1015 citations.

Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects.

Abstract: Avermectins are a group of drugs that occurs naturally as a product of fermenting Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures, including ivermectin, abamectin, doramectin, eprinomectin, moxidectin, and selamectin, were isolated and divided into four major components (A1a, A2a, B1a and B2a) and four minor components (A1b, A2b, B1b, and B2b). Avermectins are generally used as a pesticide for the treatment of pests and parasitic worms as a result of their anthelmintic and insecticidal properties. Additionally, they possess anticancer, anti-diabetic, antiviral, antifungal, and are used for treatment of several metabolic disorders. Avermectin generally works by preventing the transmission of electrical impulse in the muscle and nerves of invertebrates, by amplifying the glutamate effects on the invertebrates-specific gated chloride channel. Avermectin has unwanted effects or reactions, especially when administered indiscriminately, which include respiratory failure, hypotension, and coma. The current review examines the mechanism of actions, biosynthesis, safety, pharmacokinetics, biological toxicity and activities of avermectins.

Antimicrobial activity of Nigerian medicinal plants.

Abstract: Antimicrobial resistance (AMR) is currently one of the major threats facing mankind. The emergence and rapid spread of multi- and pan-drug-resistant organisms (such as vancomycin-, methicillin-, extended -spectrum β-lactam- , carbapenem- and fosfomycin-resistant organisms) has put the world in a dilemma. The health and economic burden associated with AMR on a global scale is dreadful. Available antimicrobials have been misused and are almost ineffective with some of these drugs associated with dangerous side effects in some individuals. Development of new, effective and safe antimicrobials is one of the ways by which AMR burden can be reduced. The rate at which microorganisms develop AMR mechanisms outpaces the rate at which new antimicrobials are being developed. Medicinal plants are potential sources of new antimicrobial molecules. There is renewed interest in antimicrobial activities of phytochemicals. Nigeria boasts of a huge heritage of medicinal plants and there is avalanche of researches that have been undertaken to screen antimicrobial activities of these plants. Scientific compilation of these studies could provide useful information on the antimicrobial properties of the plants. This information can be useful in the development of new antimicrobial drugs. This paper reviews antimicrobial researches that have been undertaken on Nigerian medicinal plants.

Awareness and use of Web 2.0 tools by librarians in university libraries in Nigeria

Abstract: Purpose – The study aims to investigate the level of awareness and use of Web 2.0 tools by librarians in university libraries in Nigeria.Design/methodology/approach – A questionnaire was used to collect data from 176 librarians in 49 university libraries in Nigeria.Findings – It emerged that the librarians were more familiar with social networking sites, instant messaging, media sharing sites, blogs and wikis. The popularity of these Web 2.0 tools made them the most frequently used by the librarians. Web 2.0 tools like Flickr, RSS feeds, podcasts, social bookmarking, were among the least used. The study revealed that librarians use Web 2.0 tools mostly for reference services online, library news/events, training resources, and image and video sharing. Lack of facilities such as computers with internet access, lack of skills, and lack of time were indicated as some of the barriers in the use of Web 2.0 tools by librarians in university libraries in Nigeria.Practical implications – These research results ca...

Covid-19 lockdown and physical distancing policies are elitist: towards an indigenous (Afro-centred) approach to containing the pandemic in sub-urban slums in Nigeria

Abstract: This study explores the experience of the sub-urban slum residents in Okpoko (Anambra State), Ngwa-road Aba (Abia State), Ajegunle (Lagos State) and Gwagwalada (Abuja), to underscore the elitist an...