Showing papers by "German Red Cross published in 1994"
TL;DR: A characteristic “juvenile” pattern of FAS is described, which may help to identify this syndrome even in adolescence and is especially relevant for patients who were not diagnosed earlier.
Abstract: At present, alcohol is recognized as the leading teratogenic agent in long-lasting CNS dysfunction. Little is known about the long-term development and outcome of children with fetal alcohol syndrome (FAS). Forty-four FAS patients who were diagnosed in early childhood were followed up for 10-14 years. This study documents the developmental changes of the manifestations of FAS from childhood to adolescence and describes a characteristic "juvenile" pattern of FAS, which may help to identify this syndrome even in adolescence. This is especially relevant for patients who were not diagnosed earlier.
67 citations
TL;DR: Two hybridoma cell lines secreting human monoclonal antibodies to the 22-kD nucleocapsid protein (core, p22) of the hepatitis C virus (HCV) are established and a linear epitope recognized by the Ul/F10 antibody on the nucleocapping protein is defined.
Abstract: In this study we describe the establishment of two hybridoma cell lines secreting human monoclonal antibodies to the 22-kD nucleocapsid protein (core, p22) of the hepatitis C virus (HCV). ...
27 citations
TL;DR: The data indicate that the MB/light treatment of FFP is an effective method to eliminate the risk of HIV-1 infection through use of the product, especially for those cases in which the plasma is collected during the 'window period' between infection of the donor and the subsequent seroconversion.
22 citations
TL;DR: This article reviews the mode of action of pharmacologic agents for anti-thrombotic therapy and refers to both clinically established drugs and new approaches currently under preclinical or clinical development.
14 citations
TL;DR: A retrospective study to determine the risk of red cell alloimmunization and transfusion during pregnancy andSerological factors as possible causes in spontaneous abortions.
8 citations
TL;DR: Interestingly, the anti-C34–39 response correlates with the presence of HCV RNA; 95.5% of the samples had coincident results in all subgroups, and none of the RIBA-negative sera showed a specific seroreaction to the C34-39 peptide.
Abstract: In this study we tested the seroreactivity of 223 selected anti-HCV-reactive blood donors to the human B-cell epitope N-VYLLPR-C (C34–39) of the hepatitis C virus core antigen. The epitope was recently identified and characterized by the human monoclonal IgG antibody Ul/F10 [23] and is located within the amino acid residues 34–39 of the aminoterminal core region. The blood donor sera were selected from anti-HCV ELISA (Ortho, 2nd generation)-reactive samples. Sixty-seven of these sera were further reactive in RIBA (Ortho, 2nd generation). According to their RIBA pattern, these samples were divided into four groups. Samples in the first group (n=18) reacted to all four recombinant HCV antigens. The samples of the second (n=9) and third group (n=8) reacted to c223/c33c and c22-3/cl00-3, respectively. Sera from group 4 (n=32) showed a RIBA indeterminate pattern with reactivity only to c22-3. All 223 samples were analyzed for anti-C34–39 antibodies by ELISA, and the 67 RIBA-reactive samples were additionally tested for the presence of HCV RNA by RT/PCR. In groups 1 and 2, over 80% of the samples showed anti-C34–39 reactivity which was restricted to the IgG1 isotype. In contrast, in groups 3 and 4, antibodies to the epitope C34–39 were detected in less than 10% of the samples. Interestingly, the anti-C34–39 response correlates with the presence of HCV RNA; 95.5% of the samples had coincident results in all subgroups. None of the RIBA-negative sera showed a specific seroreaction to the C34–39 peptide.
8 citations
01 Jan 1994
TL;DR: The identification of two IgM reactive specimens in the Frankfurt population suggest that it is possible to encounter acute hepatitis E in a blood donor population with subclinical course in Europe, and the results show a l%–2% seropositive rate in the European donors.
Abstract: Recently, acute cases of hepatitis E have been reported in Europe in conjunction with trips to countries to which HEV is endemic. To assess the seropositivity to HEV in Europe and the Middle East, we have started a multicenter study and report the initial findings here. Two recombinant antigens (8-5 and SG3) from the Burmese strain of HEV were used to develop enayme immunoassays (EIA) for the detection of IgG and IgM antibodies to HEV. Reactivity was confirmed using recombinant antigens in a Western blot and synthetic peptides in EIAs. The results showed a l%–2% seropositive rate in the European donors. In the Saudi Arabian donors (comprised of several Middle Eastern nationalities) the rate was 9%. The identification of two IgM reactive specimens in the Frankfurt population suggest that it is possible to encounter acute hepatitis E in a blood donor population with subclinical course in Europe.
8 citations
TL;DR: During the same procedure a segmental resection of the dorsal interosseous nerve can be performed, without any danger of rotational malposition.
Abstract: Surgical Principles A 6-hole DCP for 3.5 mm screws will be adapted to the radius before the osteotomy and 2 holes will be drilled on each side in an eccentric position. After osteotomy and resection the gap will be closed using the compression principle without any danger of rotational malposition. During the same procedure a segmental resection of the dorsal interosseous nerve can be performed.