Showing papers by "Hai phong University Of Medicine and Pharmacy published in 1996"
TL;DR: The active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3), has important immunomodulating effects in vitro and in animal models of transplantation and autoimmune diseases.
Abstract: The active form of vitamin D, calcitriol (1,25-dihydroxyvitamin D3), has important immunomodulating effects in vitro and in animal models of transplantation and autoimmune diseases. There is increasing evidence of cooperative effects between calcitriol and other immunosuppressants. New synthetic vitamin D analogues show much attenuated toxicity when compared with calcitriol while retaining their immunosuppressive properties. Subtherapeutic doses of such analogues might therefore be used as dose-reducing agents for classical immunosuppressants.
12 citations
01 Jan 1996
TL;DR: In this article, the authors used cyclodextrin derivatives (CDs) as inclusion complex-forming agents to increase the solubility of drugs and different dyes are also available to prevent photo-degradation of these molecules.
Abstract: Nifedipine (Nif) and its derivatives (Nifs), such as nimodipine (Nim), nisoldipine (Nis) and nitrendipine (Nit), are frequently used antianginal, anti-hypertensive or cerebral vasodilator pharmacons. They have two main disadvantages: they are practically insoluble in water and they are light-sensitive in solution [1-3]. Cyclodextrin derivatives (CDs) may be used as inclusion complex-forming agents to increase the solubility of drugs and different dyes are also available to prevent the photo-degradation of these molecules [4-5].
2 citations
01 Jan 1996
TL;DR: The effects of magnesium, calcium and lithium on the lesions produced by intravenous administration of PAF in rats were investigated and it is shown that these effects are related to ulceration and hemorrhages.
Abstract: The Platelet Activating Factor (PAF) is a lipidic autacoid having the structure 1-O-alkyl-2-acetyl-sn-glyceryl-3′-phosphorylcholine and is widely spread in a great variety of human and animal tissues (1–3). Numerous physiological and pathological involvements of PAF are known. Several authors (1,4–6) have shown that PAF produces ulceration and hemorrhages in the digestive tract. The ulcerogenic effect of PAF was observed after intravenous or topical administration at the gastric mucosa level. The mechanisms through which PAF exerts its lesional activity at the level of gastric mucosa are very complex and not completely identified. Among mechanisms proposed to explain the ulcerogenic effects of PAF are: damages of microcirculation of gastric mucosa (7), increase of free radical production (8), increase of acid secretion, formation of platelets microaggregates, increase of aggregation of neutrophils and release of lysosomal enzymes (9). In this paper, the effects of magnesium, calcium and lithium on the lesions produced by intravenous administration of PAF in rats were investigated.