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31 Aug 2021
526 citations
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TL;DR: Patency was adversely affected in patients with diabetes or with long-segment stenoses, and modifications of equipment and technique that may improve long-term patency rates are discussed.
Abstract: Short-term results of superficial femoral artery and popliteal percutaneous transluminal angioplasty have been good, but long-term results and factors influencing long-term patency are less commonly reported. One hundred thirty-seven superficial femoral artery angioplasties with follow-up for 54 months were reviewed. The 4-year patency for stenoses was 61% and for occlusions was 68%. If the initial result was clinically successful, the 4-year patency was not influenced by the quality or patency of runoff or by the length of the occlusion. Nineteen patients returned for redilatation, eight of whom had developed new lesions. Patency was adversely affected in patients with diabetes or with long-segment stenoses. Modifications of equipment and technique that may improve long-term patency rates are discussed.
121 citations
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TL;DR: Ganetespib is well tolerated as a weekly infusion for 3 of every 4 weeks cycle, and the recommended phase II dose is 200 mg/m2, and is associated with an acceptable tolerability profile.
Abstract: Background: This phase I study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics and antitumor activity of ganetespib in patients with solid malignancies. Methods: Patients were enrolled in cohorts of escalating ganetespib doses, given as 1 hour IV infusion, once weekly for 3 weeks, followed by a 1-week rest until disease progression or unacceptable toxicity. Endpoints included safety, pharmacokinetic and pharmacodynamic parameters and preliminary clinical activity. Results: Fifty-three patients were treated at doses escalating from 7 to 259 mg/m 2 . The most common adverse events were Grade 1 and 2 diarrhea, fatigue, nausea or vomiting. Dose-limiting toxicities (DLT) observed were: one Grade 3 amylase elevation (150 mg/m 2 ), one Grade 3 diarrhea and one Grade 3 and one Grade 4 asthenia (259 mg/m 2 ). The MTD was 216 mg/m 2 and the recommended phase 2 dose was established at 200 mg/m 2 given IV at Days 1, 8, and 15 every 4 weeks. There was a linear relationship between dose and exposure. Plasma HSP70 protein levels remained elevated for over a week post treatment. Disease control rate (objective response and stable disease at ≥ 16 weeks) was 24.4%. Conclusions: Ganetespib is well tolerated as a weekly infusion for 3 of every 4 weeks cycle. The recommended phase II dose is 200 mg/m 2 , and is associated with an acceptable tolerability profile. Trial registration: NCT00687934
106 citations
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TL;DR: It is suggested that the Sim-EHR curriculum is an effective, interactive method for providing learners with EHR skills education while demonstrating how a well-organized chart helps ensure safe, efficient, and quality patient care.
Abstract: Electronic health records (EHRs) can improve many aspects of patient care, yet few formal EHR curricula exist to teach optimal use to students and other trainees. The Simulated EHR (Sim-EHR) curriculum was introduced in January 2011 at Oregon Health & Science University (OHSU) to provide learners with a safe hands-on environment in which to apply evidence-based guidelines while learning EHR skills. Using an EHR training platform identical to the OHSU EHR system, learners review and correct a simulated medical chart for a complex virtual patient with chronic diseases and years of fragmented care. They write orders and prescriptions, create an evidence-based plan of care for indicated disease prevention and management, and review their work in a small-group setting. Third-year students complete the Sim-EHR curriculum as part of the required family medicine clerkship; their chart work is assessed using a rubric tied to the curriculum's general and specific objectives. As of January 2014, 406 third-year OHSU medical students, on campus or at remote clerkship sites, and 21 OHSU internal medicine interns had completed simulated charts.In this article, the authors describe the development and implementation of the Sim-EHR curriculum, with a focus on use of the curriculum in the family medicine clerkship. They also share preliminary findings and lessons learned. They suggest that the Sim-EHR curriculum is an effective, interactive method for providing learners with EHR skills education while demonstrating how a well-organized chart helps ensure safe, efficient, and quality patient care.
71 citations
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MetroHealth1, Harvard University2, University of North Carolina at Chapel Hill3, University of Miami4, Boston College5, Kettering Health Network6, University of Pennsylvania7, University of Massachusetts Boston8, Emory University9, Pennsylvania State University10, Loma Linda University11, Johns Hopkins University12, Urban Institute13
65 citations
Authors
Showing all 80 results
Name | H-index | Papers | Citations |
---|---|---|---|
Monte S. Buchsbaum | 107 | 462 | 34841 |
Robert I. White | 58 | 274 | 14249 |
Randy A. Sansone | 41 | 340 | 5755 |
Douglas S. Lehrer | 16 | 35 | 1637 |
Richard Simman | 16 | 52 | 1012 |
Bingzhi Shi | 16 | 21 | 1020 |
Colwick Wilson | 13 | 43 | 641 |
Anthony J. Paravati | 10 | 19 | 319 |
Robert R. Murray | 10 | 10 | 801 |
M. D. Boska | 9 | 10 | 622 |
Jason G. Parker | 6 | 22 | 176 |
H. Brent Bamberger | 5 | 10 | 178 |
Lyndsay L. Madden | 4 | 23 | 45 |
Arash Kardan | 3 | 7 | 31 |
Eric J. Zalusky | 2 | 4 | 27 |