Showing papers by "Korea University published in 1978"

Anthelmintic effects of various drugs against metagonimiasis

Abstract: The infection of Metagonimus yokogawai has been known to be present nationwidely and endemic in some parts in Korea. In order to select a highly effective compound against Metagonimus infections, the therapeutic effects were observed in 156 cases who were treated with several anthelmintic i.e. bithionol, niclosamide, niclofolan and praziquantel. All of the above drugs showed highly effective to the treatment of metagonimiasis by a single or two medication days. The egg reduction rates were in the range of 80.2 to 100 per cent. However, relatively low cure rates(8.3 to 37.5%) were observed in the groups treated by two doses of 30 mg/kg of bithionol, a single day treatment with 100 mg/kg of niclosamide and two doses of 1.0 mg/kg of niclofolan. On the other hand, the high cure rates were observed at the following dose rates of each drugs, i.e. the cure rate of 66.7% was obtained at two doses of 100 mg/kg of niclosamide, 88.9% of cure rate was observed at two doses of 2.0 mg/kg of niclofolan and a single dose of 10 and 20 mg/kg of praziquantel were shown as 85.0% and 88.0% of cure rates respectively. But the complete radical cure was obtained in the group treated by two doses of 20 mg/kg of praziquantel in 10 metagonimiasis cases. From the above results praziquantel was shown as the most highly effective against metagonimiasis and it was well tolerated without any side effect. Therefore, praziquantel is a very promising drug for mass treatment against metagonimiasis.

Therapeutic Effects Of Praziquantel (Embay 8440) Against Hymenolepis Nana Infection.

Abstract: A total of 60 patients with Hymenolepis nana infection were treated with a single oral dose of praziquantel in two different dose levels. Twenty-nine cases treated with praziquantel in a single dose of 15 mg/kg body weight produced a 100% cure rate. On the otehr hand, 30 out of 31 patients who received a single dose of 25 mg/kg body weight cured completely, but only one case had counts of 200 EPG of feces in each tests on the 20th and 21st days after treatment. The cure rate was 96.8% and the mean egg reduction rate of 99.8 per cent was obtained. Side effects were mild and transitory. In a few cases, abdominal pain, vertigo, headache and diarrhea were complained in a few hours after medication. Clinial hematology, serum biochemistry and urinalysis were performed immediately before and the next day after treatment in all cases. There were no significant abnormalities detected in these tests.

Geochemistry and origin of amphibolite and magnetite from the Yangyang iron deposit in the Gyeonggi metamorphic complex, Republic of Korea

Abstract: The chemical similarity of magnetite-bearing amphibolites from the Yangyang iron mine in Korea to mixtures of pelite and limestone or dolomite is consistently indicated by all the available chemical data. The chemical variation trends of the rocks were compared with ortho-(discordant-) and massive amphibolites from the Gyeonggi metamorphic complex, Korea. Samples of nine amphibolites from the Yangyang mine, and two ortho-amphibolites and six massive amphibolites from the Gyeonggi metamorphic complex were analyzed for twenty-two elements by wet-chemical, X-ray fluorescence and emission-spectroscopic methods. Trace-element analyses of the magnetites from the Yangyang mine were compared to those from a deposit of magmatic-segregation type and from six Precambrian sedimentary magnetite deposits found elsewhere in Korea. It is suggested that the magnetite ore may have been derived by metamorphism of iron-rich sediment originally deposited in an environment of pelite-carbonate sedimentation.

Effect Of Oxantel/pyrantel Pamoate Tablets Against Intestinal Nematodes In Korea.

Abstract: A total of 48 subjects harbouring Trichuris trichiura, Ascaris lumbricoides, hookworm and/or Enterobius vermicularis were treated with oxantel/pyrantel pamoate tablets (100 mg of each) in a single dose of 20 mg base per kg of body weight. In all 37 cases of A. lumbricoides and 8 cases of A. duodenale infections cured completely, and the mean recovered worm-load was 3.8 with a range of 1-21 and 5.8 with a range of 3-9 respectively. In T. trichiura infection, 32(71.1%) of 45 cases cured completely and the average egg reduction rate was 90.8 per cent. The mean recovered worm-load was 14.6 with a rnage of 1-77 worms. On the other hand, in E. vermicularis infection, 37 (84.1%) of 44 patients were negative eggs by anal swab tests on the 10 to 11th days and 27 (61.4%) on the 20 to 21st days after treatment. The mean recovered worm-load was 17.7 with a range of 1-62. Only one patient with Trichostrongylus orientalis treated with this drug showed no eggs in his stools throughout the post-treatment examinations. Side effects were not noted in all treated cases. These findings demonstrate that a single dose of oxantel/pyrantel pamoate tablets can be considered a drug of choice for multiple infections with these nematodes.

Crystal Growth and Chemical Preferential Etching in Fabrication of Epitaxial Silicon Detectors

Abstract: The chemical preferential etching technique is applied on fabrication of thin silicon detectors with uniformL thicknesses. For this purpose, the silicon epitaxial wafers which have high resistivities and uniform impurity profiles with abrupt interfaces between epitaxial layers and substrates are required. Crystal growth techniques used for satisfying these requirements are described. Chemical etching processes employed for performing uniform dissolution of the substrate and for maintaining a large difference of etching rates in low and high resistivity silicon layers are also described. The donor impurities doped in substrates are antimony (Sb) and arsenic (As). The effects of impurities upon the fabrication of detectors are discussed considering the characteristics of these dopants.

Epidemiological Study On The Hookworm Infections In Korea

Abstract: This study was undertaken to evaluate the present status of hookworm infections in Korea from October 1976 through September 1978. The stool specimens of 5,632 persons(male 3,689: female 1,943) collected from primary and middle schools, foundling asylums, and the general populations of various parts in Korea were examined The methods employed were brine floatation technique for the prevalence rate of hookworm infections, Kato's cellophane thick smear technique for the other helminthic infections, and Stoll's dilution egg counting technique for the intensity of hookworm infections. Ancylostoma duodenale and Necator americanus infections were classified by polyethylene tube coproculture method and by the evacuated adult worms after administration of anthelmintics against the patients infected with hookworms. The following results were obtained in this study. 1. The prevalence rate of hookworm infections in rural area was higher than in urban area in the ratio of 2.4:1. And in the age group of over 20, the prevalence rate in significantly higher than that in urban area in the ratio of 5.8:1. 2. In the urban area, difference in the prevalence rate of hookworm infections between the age group of over 20 and that of under 19 was not observed. But in the rural area, the ratio of the prevalence rate between the age group of over 20 to that of under 19 was 8:1. 3. The prevalence rate of hookworm infections in female was higher than that in male in all age group except the age group of under 9 and 20~29. The ratio of the prevalence rate between female to male was 1.5:1 in total population. 4. The area which showed the mean E.P.G. of over 1,000 was not found and almost all of the patients who were infected with hookworms gave the mean E.P.G. between l~999. 5. Necator americanus was newly found in Dangjin Gun, Boseong Gun, Habcheon Gun and Weonseong Gun. In these 4 newly found areas, Dangjin Gun and Boseong Gun showed the composition rate of 25.5% and 83.4% respectively.